Nearby Construction Impedes the Progression to Overt Autoimmune Diabetes in NOD Mice
Nearby Construction Impedes the Progression to Overt Autoimmune Diabetes in NOD Mice
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DOI：
10.1155/2013/620313
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发表时间：
2013-01-01
影响因子：
4.3
通讯作者：
Lesage, Sylvie
中科院分区：
文献类型：
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作者：
Hillhouse, Erin E.;Collin, Roxanne;Lesage, Sylvie
偶尔有报道称，在动物舍附近建造房屋会影响动物健康的各个方面。大多数报告都集中在对应激激素水平的影响和动物相对于人类的超敏反应。也有关于NOD小鼠中建筑对自身免疫性糖尿病的影响的轶事报道。在这里，我们描述了附近的建设显着阻碍进展，以显性糖尿病的雌性NOD小鼠后代。我们证明，这不是由于遗传漂变或与我们特定小鼠群体相关的特殊性造成的。有趣的是，虽然在妊娠期间受到施工压力的母亲所生的小鼠中，胰岛素水平仍然很低，但我们检测到对胰岛细胞的主动自身免疫反应，如通过胰岛炎程度和血清中胰岛素自身抗体水平的存在所测量的。这些结果表明，在胚胎发育过程中施加的外部压力并不能阻止，但显着延迟自身免疫过程。总之，我们的研究结果强调了在体内研究中周围因素的影响，并与环境和遗传因素都有助于自身免疫性糖尿病发展的假设一致。
Construction nearby animal houses has sporadically been reported to affect various aspects of animal health. Most of the reports have focussed on the impact on stress hormone levels and the hypersensitivity of animals relative to humans. There has also been an anecdotal report on the impact of construction on autoimmune diabetes in NOD mice. Here, we describe that nearby construction significantly impedes the progression to overt diabetes in female NOD mice offspring. We demonstrate that this was not due to a genetic drift or to particularities associated with our specific mouse colony. Interestingly, although the glycemia levels remained low in mice born from mothers subject to construction stress during gestation, we detected an active autoimmune reaction towards pancreatic islet cells, as measured by both the degree of insulitis and the presence of insulin autoantibody levels in the serum. These results suggest that the external stress imposed during embryonic development does not prevent but significantly delays the autoimmune process. Together, our findings emphasize the impact of surrounding factors during in vivo studies and are in agreement with the hypothesis that both environmental and genetic cues contribute to autoimmune diabetes development.