Coiled coils and SAH domains in cytoskeletal molecular motors
Coiled coils and SAH domains in cytoskeletal molecular motors
复制标题
DOI：
10.1042/bst0391142
复制
发表时间：
2011-10-01
影响因子：
3.9
通讯作者：
Peckham, Michelle
中科院分区：
文献类型：
--
作者：
Peckham, Michelle
细胞骨架马达包括肌球蛋白、驱动蛋白和动力蛋白。肌球蛋白沿着肌动蛋白丝的轨迹运动，而驱动蛋白和动力蛋白则沿着沿着微管运动。这些发动机中的许多都参与了细胞中货物的运输。然而，肌球蛋白大多是单体的，而驱动蛋白大多是二聚体的，这是由于存在卷曲螺旋。一些肌球蛋白（肌球蛋白6、7和10）含有SAH（单α螺旋）结构域，其最初被认为是卷曲螺旋。现在已知这些肌球蛋白是单体，而不是二聚体。SAH结构域和卷曲螺旋之间的差异进行了描述和SAH结构域在分子马达的潜在作用进行了讨论。
Cytoskeletal motors include myosins, kinesins and dyneins. Myosins move along tracks of actin filaments, whereas kinesins and dyneins move along microtubules. Many of these motors are involved in trafficking cargo in cells. However, myosins are mostly monomeric, whereas kinesins are mostly dimeric, owing to the presence of a coiled coil. Some myosins (myosins 6, 7 and 10) contain an SAH (single alpha-helical) domain, which was originally thought to be a coiled coil. These myosins are now known to be monomers, not dimers. The differences between SAH domains and coiled coils are described and the potential roles of SAH domains in molecular motors are discussed.