Lean body mass but not body fat mass is related with leukocyte telomere length in children
Lean body mass but not body fat mass is related with leukocyte telomere length in children
复制标题
儿童的去脂体重而非体脂量与白细胞端粒长度相关
DOI：
10.1038/s41366-022-01239-4
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发表时间：
2022-11-17
影响因子：
4.9
通讯作者：
Liang, Jingjing
中科院分区：
文献类型：
--
作者：
Hong, Zhen;Lin, Xiaoping;Liang, Jingjing
目的探讨6~11岁健康儿童的体成分与白细胞端粒长度(LTL)的关系。方法对406名健康儿童进行横断面研究，其中女孩175名，男孩231名。用定量聚合酶链式反应测定外周血白细胞端粒相对长度。采用双能X线骨密度仪测定体脂含量和局部脂肪分布，测定全身(TB)和全身无头(TBLH)水平的附件骨肌质量(ASM)、骨密度(BMD)和骨矿含量(BMC)，并测定全身瘦质量(TBLM)。计算ASM/Height(2)(ASMI)。结果调整可能的协变量后，多元线性回归分析显示，体脂含量和体脂分布与下限无关(β=-8.48x10(-6)-1.44x10(-1)，p=0.227~0.959)。ASM、ASMI、TB BMC/TB BMD、TBLHBMC/TBLHBMD和TBLm与LTL呈正相关(β=8.95x10(-6)-4.95x10(-1)，p=0.005~0.035)。此外，协方差分析显示，LTL与ASM、TB BMC/BMD、TBLHBMC/BMD和TBLm呈剂量依赖性正相关(p趋势=0.002-0.025)。结论在这一儿童人群中，骨骼肌量和骨量与LTL显著相关，而与体脂含量或分布无关。
Objectives The aim of this study was to investigate the relationship between body composition and leukocyte telomere length (LTL) in healthy Chinese children aged 6-11 years. Methods This cross-sectional study enrolled 406 healthy children (175 girls and 231 boys). The relative telomere length in their peripheral blood leukocytes was determined via quantitative polymerase chain reaction. Dual-energy X-ray absorptiometry was used to determine body fat content and regional fat distribution, appendicular skeletal muscle mass (ASM), bone mineral density (BMD) and bone mineral content (BMC) at the total body (TB) and total body less head (TBLH) levels, and total body lean mass (TBLM) was then determined. ASM/height(2) (ASMI) was also calculated. Results After adjusting for potential covariates, multiple linear regression analyses revealed that neither body fat content nor regional body fat distribution were significantly associated with LTL (beta = -8.48 x 10(-6)-1.44 x 10(-1), p = 0.227-0.959). However, ASM, ASMI, TB BMC/TB BMD, TBLH BMC/TBLH BMD and TBLM were positively associated with LTL (beta = 8.95 x 10(-6)-4.95 x 10(-1), p = 0.005-0.035). Moreover, analysis of covariance revealed there was a statistically significant dose-dependent positive association between LTL and ASM, TB BMC/BMD, TBLH BMC/BMD, and TBLM (p-trend = 0.002-0.025). Conclusions Skeletal muscle mass and bone mass but not body fat content or distribution were significantly associated with LTL in this pediatric population.