Synthesis of imidazo[1,2-a]pyridines as antiviral agents
Synthesis of imidazo[1,2-a]pyridines as antiviral agents
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DOI：
10.1021/jm981051y
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发表时间：
1998-12-03
影响因子：
7.3
通讯作者：
Chapat, JP
中科院分区：
文献类型：
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作者：
Gueiffier, A;Mavel, S;Chapat, JP
报道了3位含硫醚侧链的咪唑并[1，2-a]吡啶类化合物的合成及其抗病毒活性。从合成的化合物中，4、15和21对人巨细胞病毒具有高度活性，治疗指数上级超过150。这些化合物还显示出显著的抗水痘-带状疱疹病毒活性。讨论了它们的构效关系。
The synthesis of original imidazo[1,2-a]pyridines bearing a thioether side chain at the 3 position and their antiviral activity are reported. From the synthesized compounds, 4, 15, and 21 were highly active against human cytomegalovirus with a therapeutic index superior to 150. These compounds also showed pronounced activity against varicella-zoster virus. Their structure-activity relationship is discussed.