Near Full-Length Genome Sequence of a Novel HIV-1 Recombinant Form (CRF01_AE/07_BC) Detected Among Men Who Have Sex with Men in Zhejiang, China
Near Full-Length Genome Sequence of a Novel HIV-1 Recombinant Form (CRF01_AE/07_BC) Detected Among Men Who Have Sex with Men in Zhejiang, China
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在中国浙江男男性行为者中检测到新型 HIV-1 重组体 (CRF01_AE/07_BC) 的近全长基因组序列
DOI：
10.1089/aid.2018.0135
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Yiming Shao
中科院分区：
文献类型：
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作者：
Jia Sun;Biao Zhu;Yi Feng;Yirui Xie;Ying Huang;Weidong Ou;Zehua Zhou;Kang Li;Zhangwen Ge;Hui Xing;Yiming Shao
中国地区男男性行为者(MSM)中HIV 1型感染率呈上升趋势。本文报道了从浙江省东部中国地区一名男性患者中发现的一种新的HIV-1重组株(CRF01AE/CRF07BC)。近全长基因组分析表明，HIV-1重组毒株(16ZJ305)在env区和Tat/revgene区有两个重组断裂点。到目前为止，已鉴定出几种新的CRF01_AE/CRF07_BC重组形式，这可能表明HIV-1感染在MSM中存在活跃的传播网络。进一步研究男男性接触者中HIV-1流行的分子流行病学对于更好地了解传播网络和追踪遗传进化是必要的。
The prevalence of HIV type 1 among men who have sex with men (MSM) is increasing in China. We report here a novel HIV-1 recombinant form (CRF01_AE/CRF07_BC) detected from a male patient infected with HIV-1 by homosexual behavior in Zhejiang Province of eastern China. The near full-length genome analyses showed that the unique HIV-1 recombinant isolate (16ZJ305) has two recombinant breakpoints observed in theenv and tat/revgene regions. To date, several novel CRF01_AE/CRF07_BC recombinant forms have been identified, which may imply an active transmission network of HIV-1 infection among MSM. Further studies of the molecular epidemiology of the HIV-1 epidemic among MSM are necessary to gain a better understanding of the transmission network and track the genetic evolution.