Glutamate-mediated selective vulnerability to ischemia is present in organotypic cultures of hippocampus.
Glutamate-mediated selective vulnerability to ischemia is present in organotypic cultures of hippocampus.
复制标题
谷氨酸介导的选择性缺血脆弱性存在于海马器官型培养物中。
DOI：
10.1016/0304-3940(90)90095-q
复制
发表时间：
1990
影响因子：
2.5
通讯作者：
Franck,JE
中科院分区：
文献类型：
--
作者：
Newell,DW;Malouf,AT;Franck,JE
Ischemic damage to the brain, whether induced experimentally or observed clinically, often produces a pattern of delayed selective cell death in subfield CA1 of hippocampus which has been associated with significant neurologic deficits. The present study demonstrates that this selective vulnerability of CA1 neurons to ischemia, with relative preservation of their neighbors, is expressed in organotypic tissue culture and is prevented by the N-methyl-d-aspartate (NMDA) receptor blocker, MK-801. These data provide conclusive evidence that this selective cells death does not have a vascular etiology but is mediated by factors intrinsic to the hippocampal neurons and/or local circuitry. This model system provides an opportunity both to examine mechanisms of ischemic cell death in an avascular environment and to study methods of prevention in the absence of systemic variables.
