Two decades of progress in structural and dynamic studies of amyloids by solid-state NMR
Two decades of progress in structural and dynamic studies of amyloids by solid-state NMR
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DOI：
10.1016/j.jmr.2019.07.015
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发表时间：
2019-09-01
影响因子：
2.2
通讯作者：
Jaroniec, Christopher P.
中科院分区：
文献类型：
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作者：
Jaroniec, Christopher P.
在这篇透视文章中，我简要地强调了在过去的二十年中，在原子水平上的淀粉样蛋白，这是非结晶生物大分子组件的代表，通过魔角旋转固态NMR光谱的结构和动态研究取得的快速进展。鉴于固态NMR仪器和方法的新的和持续的发展，在这一领域正在进行的研究有望有助于提高对淀粉样蛋白结构，多态性，相互作用，组装机制，生物功能和毒性的理解。(C)2019爱思唯尔公司All rights reserved.
In this perspective article I briefly highlight the rapid progress made over the past two decades in atomic level structural and dynamic studies of amyloids, which are representative of non-crystalline biomacromolecular assemblies, by magic-angle spinning solid-state NMR spectroscopy. Given new and continuing developments in solid-state NMR instrumentation and methodology, ongoing research in this area promises to contribute to an improved understanding of amyloid structure, polymorphism, interactions, assembly mechanisms, and biological function and toxicity. (C) 2019 Elsevier Inc. All rights reserved.