Emotional stress- and pain-related behaviors evoked by experimental tooth movement.
Emotional stress- and pain-related behaviors evoked by experimental tooth movement.
复制标题
DOI：
10.2319/040207-165.1
复制
发表时间：
2008-05
期刊：
影响因子：
--
通讯作者：
Joseph H Yozgatian;J. Zeredo;H. Hotokezaka;Y. Koga;K. Toda;N. Yoshida
中科院分区：
文献类型：
--
作者：
Joseph H Yozgatian;J. Zeredo;H. Hotokezaka;Y. Koga;K. Toda;N. Yoshida
目的采用行为学方法研究大鼠实验性牙齿移动过程中情绪应激与疼痛的关系。材料与方法16只雄性Sprague-Dawley大鼠（210 ~ 250 g）分为两组。实验组采用主动式钛镍合金矫治器，对照组采用被动式矫治器。主动矫治器在上颌第一磨牙和第二磨牙之间施加20 gf的力，持续3天。在此期间，通过旷场实验和抗捕捉实验对大鼠的行为进行了8次评估。动物活动的具体参数是面部梳理，饲养，和运动活动，运动到开放领域的中心，并响应捕获。结果与被动矫治器组相比，主动矫治器组的压力和疼痛相关参数更高。实验组和对照组之间的压力相关行为的统计学显着差异被发现放置器具后8小时，并在第二天最明显。在24小时时，实验组的疼痛相关行为显著高于对照组。结论正畸牙移动引起的情绪应激的增加可能先于牙周疼痛的出现。
OBJECTIVE To investigate by behavioral methods the relationship between emotional stress and pain during experimental tooth movement in rats. MATERIALS AND METHODS Sixteen male Sprague-Dawley rats (210 to 250 g) were divided into two groups. The experimental group was treated with an active Ti-Ni appliance, and the control group received a passive appliance. A force of 20 gf was delivered by the active appliance between the maxillary first and second molars for 3 days. During this period the rat's behavior was evaluated eight times by means of open-field test and resistance-to-capture test. The specific parameters of animal activity were facial grooming, rearing, and locomotor activity, movement into the center of the open field, and response to capture. RESULTS Parameters related to stress and pain were higher in the group carrying active appliance, compared to the group with a passive appliance. Statistically significant differences in stress-related behavior between control and experimental groups were found 8 hours after placing the appliance and were most evident on the second day. Pain-related behavior was significantly greater in the experimental group than in the control group at 24 hours. CONCLUSIONS The increase in emotional stress evoked by orthodontic tooth movement may precede the appearance of periodontal pain.