Replication Study Supports CTNND2 as a Susceptibility Gene for High Myopia
Replication Study Supports CTNND2 as a Susceptibility Gene for High Myopia
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DOI：
10.1167/iovs.11-7914
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发表时间：
2011-10-01
影响因子：
4.4
通讯作者：
Zhang, Qingjiong
中科院分区：
文献类型：
--
作者：
Lu, Boyu;Jiang, Dan;Zhang, Qingjiong
目的. CTNND 2基因位于高度近视MYP 16位点的连锁区间，最近发现CTNND 2基因的两个单核苷酸多态性（SNPs; rs6885224和rs 12716080）与高度近视相关。本研究在一个独立的病例对照系列中评估了这种关联。本研究共纳入2773名无关个体，其中高度近视（各子午线球面屈光度）1203名
PURPOSE. The CTNND2 gene is located in the linkage interval of high myopia locus MYP16 and two single-nucleotide polymorphisms (SNPs; rs6885224 and rs12716080) in CTNND2 were recently shown to associate with high myopia. This study evaluated such associations in an independent case-control series.METHODS. A total of 2773 unrelated individuals were enrolled in this study, including 1203 subjects with high myopia (spherical refraction at each meridian