Patient and societal value functions for the testing morbidities index.
Patient and societal value functions for the testing morbidities index.
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DOI：
10.1177/0272989x13487605
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发表时间：
2013-08
期刊：
影响因子：
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通讯作者：
Donelan K
中科院分区：
文献类型：
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作者：
Swan JS;Kong CY;Lee JM;Itauma O;Halpern EF;Lee PA;Vavinskiy S;Williams O;Zoltick ES;Donelan K
我们开发了基于偏好和总和的量表评分用于测试发病率指数（TMI）分类，该分类解决了测试程序之前，期间和之后诊断测试对生活质量的短期影响。两个TMI值函数利用多属性值技术;一个是基于患者的，另一个具有社会视角。206名乳腺活检患者和466名（社会）受试者告知模型。由于该应用缺乏标准短期方法，我们使用视觉模拟量表（VAS）。等待权衡（WTO）收费提供了一个额外的选择线性转换的TMI。我们将参与者随机分配到三项调查中的一项：第一项是通过VAS得出的一般测试发病率属性和严重程度的权重;第二项是开发的VAS值和WTO收费，用于将TMI线性转换为死亡-健康量表;第三项是在特定测试（乳腺活检）中进行的初步验证。188名患者和425名社区受试者参与了初始验证，将直接VAS和WTO值与TMI进行比较。另一种TMI评分作为非偏好汇总量表，被纳入，给出了结构和内容效度的证据。患者模型可以使用加法函数，而社会模型是乘法函数。直接VAS和VAS分级的TMI在建模组间相关（r=0.45至0.62），一致性与健康效用指数2的价值函数验证相当。平均绝对差（MAD）计算显示患者的范围为0.07-0.10，受试者的范围为0.11-0.17。与WTO标准TMI相比，WTO直接收费的MAD在一个质量调整生命日附近变化很大。TMI在测量短期测试相关的健康状态方面显示出初步的承诺。
We developed preference-based and summated scale scoring for the Testing Morbidities Index (TMI) classification, which addresses short-term effects on quality of life from diagnostic testing before, during and after a testing procedure. The two TMI value functions utilize multiattribute value techniques; one is patient-based and the other has a societal perspective. 206 breast biopsy patients and 466 (societal) subjects informed the models. Due to a lack of standard short-term methods for this application, we utilized the visual analog scale (VAS). Waiting trade-off (WTO) tolls provided an additional option for linear transformation of the TMI. We randomized participants to one of three surveys: the first derived weights for generic testing morbidity attributes and levels of severity with the VAS; a second developed VAS values and WTO tolls for linear transformation of the TMI to a death-healthy scale; the third addressed initial validation in a specific test (breast biopsy). 188 patients and 425 community subjects participated in initial validation, comparing direct VAS and WTO values to the TMI. Alternative TMI scoring as a non-preference summated scale was included, given evidence of construct and content validity. The patient model can use an additive function, while the societal model is multiplicative. Direct VAS and the VAS-scaled TMI were correlated across modeling groups (r=0.45 to 0.62) and agreement was comparable to the value function validation of the Health Utilities Index 2. Mean Absolute Difference (MAD) calculations showed a range of 0.07–0.10 in patients and 0.11–0.17 in subjects. MAD for direct WTO tolls compared to the WTO-scaled TMI varied closely around one quality-adjusted life day. The TMI shows initial promise in measuring short-term testing-related health states.