Formation mechanism and hemocompatibility of the superhydrophobic surface on biomedical Ti-6Al-4V alloy
Formation mechanism and hemocompatibility of the superhydrophobic surface on biomedical Ti-6Al-4V alloy
复制标题
医用Ti-6Al-4V合金超疏水表面形成机制及血液相容性
DOI：
10.1007/s10853-020-05696-y
复制
发表时间：
2021-01-25
影响因子：
4.5
通讯作者：
Lian, L.
中科院分区：
文献类型：
--
作者：
Chen, J.;Xu, J. L.;Lian, L.
采用水热处理和后续疏水处理相结合的方法在生物医用Ti-6Al-4V合金表面制备超疏水表面。对超疏水样品的表面形貌、表面粗糙度、物相组成、元素组成、水接触角和血液相容性进行了研究。结果表明，水热处理后的样品主要由Na2Ti6O13相组成，并带有一定的-OH基团。水热处理后的样品表面形貌由羽毛状结构转变为草状结构，且随着NaOH溶液浓度的增加，表面粗糙度逐渐增大。疏水处理后，样品表面粗糙度略有减小，水接触角先增大，在3.75mol/L时达到最大值159.24°1.89度，然后随氢氧化钠浓度的增加而减小。通过自组装脱水反应，将-C8H4F13低表面能氟化物接枝到水热处理样品表面，形成超疏水表面。超疏水表面有效地降低了溶血率和血小板粘附率，延长了动态凝血时间，表明其极大地改善了生物医用钛合金的血液相容性。
The superhydrophobic surface was prepared on biomedical Ti-6Al-4V alloy by hydrothermal treatment coupled with subsequent hydrophobic treatment. The surface morphologies, surface roughness, phase and elemental compositions, water contact angle and hemocompatibility of the superhydrophobic samples were investigated. The results show that the hydrothermally treated sample is mainly composed of Na2Ti6O13 phase with some -OH groups. The surface morphologies of the hydrothermally treated samples change from feather-like structure to grass-like structure, and the surface roughness gradually increases with increasing the concentrations of NaOH solution. After hydrophobic treatment, the surface roughness of samples slightly decreases, and the water contact angles increase first, reaching the maximum value of 159.24 degrees 1.89 degrees at 3.75 mol/L, and then decrease with increasing the NaOH concentrations. The -C8H4F13 low surface energy fluorides are grafted onto the surface of hydrothermally treated sample by a self-assembly dehydration reaction, resulting in the formation of the superhydrophobic surface. The superhydrophobic surface effectively decreases the hemolysis ratio and platelets adhesion, and prolongs the dynamic coagulation time, indicating that it greatly improves the hemocompatibility of the biomedical Ti-6Al-4V alloy.[GRAPHICS].