Incidence proportions of brain metastases in patients diagnosed (1973 to 2001) in the metropolitan Detroit cancer surveillance system
Incidence proportions of brain metastases in patients diagnosed (1973 to 2001) in the metropolitan Detroit cancer surveillance system
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DOI：
10.1200/jco.2004.12.149
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发表时间：
2004-07-15
影响因子：
45.3
通讯作者：
Sawaya, RE
中科院分区：
文献类型：
--
作者：
Barnholtz-Sloan, JS;Sloan, AE;Sawaya, RE
研究目的：脑转移瘤发病率的人群估计值目前尚不普遍。本研究的目的是计算人口为基础的发病率比例（IP）的脑转移瘤从单一的原发性肺，黑色素瘤，乳腺癌，肾，或结直肠cancer.Patients和MethodsPatients诊断为单一的原发性肺，黑色素瘤，乳腺癌，肾，或结直肠癌（1973年至2001年）在底特律大都会癌症监测系统（MDCSS）被用于分析。按原发部位和关注变量列出的脑转移瘤IP（种族、性别、原发癌诊断时的年龄、原发癌的监测、流行病学和最终结果[SEER]分期）计算95%CIs.ResultsTotal IP百分比（IP%）脑转移瘤为9.6%，肺转移瘤最高（19.9%），其次是黑色素瘤（6.9%）、肾癌（6.5%）、乳腺癌（5.1%）和结直肠癌（1.8%）。在大多数原发部位，与其他种族组相比，非裔美国人的脑转移IP%较高。女性肺癌患者的IP%显著更高，男性黑色素瘤患者的IP%显著更高。脑转移瘤的最高IP%发生在不同的诊断年龄：原发性肺癌的年龄为40至49岁;原发性黑色素瘤、肾癌或结直肠癌的年龄为50至59岁;原发性乳腺癌的年龄为20至39岁。IP%显着增加SEER阶段的原发性癌症先进的所有primarysituation.ConclusionTotal IP%的脑转移瘤低于以前报道的，它不同的原发性癌症，种族，性别，年龄在诊断原发性癌症，和SEER阶段的原发性癌症。(C)2004年，美国临床肿瘤学会。
PurposePopulation-based estimates of the incidence of brain metastases are not generally available. The purpose of this study was to calculate population-based incidence proportions (IPs) of brain metastases from single primary lung, melanoma, breast, renal, or colorectal cancer.Patients and MethodsPatients diagnosed with single primary lung, melanoma, breast, renal, or colorectal cancer (1973 to 2001) in the Metropolitan Detroit Cancer Surveillance System (MDCSS) were used for analysis. IP of brain metastases by primary site and variable of interest (race, sex, age at diagnosis of primary cancer, and Surveillance, Epidemiology, and End Results [SEER] stage of primary cancer) was calculated with 95% CIs.ResultsTotal IP percentage (IP%) of brain metastases was 9.6% for all primary sites combined, and highest for lung (19.9%), followed by melanoma (6.9%), renal (6.5%), breast (5.1%), and colorectal (1.8%) cancers. Racial differences were seen with African Americans demonstrating higher IP% of brain metastases compared with other racial groups for most primary sites. IP% was significantly higher for female patients with lung cancer, and significantly higher for male patients with melanoma. The highest IP% of brain metastases occurred at different ages at diagnoses: age 40 to 49 years for primary lung cancer; age 50 to 59 years for primary melanoma, renal, or colorectal cancers; and age 20 to 39 for primary breast cancer. IP% significantly increased as SEER stage of primary cancer advanced for all primary sites.ConclusionTotal IP% of brain metastases was lower than previously reported, and it varied by primary site, race, sex, age at diagnosis of primary cancer, and SEER stage of primary cancer. (C) 2004 by American Society of Clinical Oncology.