Retinal blood flow velocity measured by retinal function imaging in retinitis pigmentosa
Retinal blood flow velocity measured by retinal function imaging in retinitis pigmentosa
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DOI：
10.1007/s00417-011-1757-y
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发表时间：
2011-12-01
影响因子：
2.7
通讯作者：
Jonas, Jost B.
中科院分区：
文献类型：
--
作者：
Beutelspacher, Sven C.;Serbecic, Nermin;Jonas, Jost B.
应用视网膜功能成像技术对视网膜色素变性（retinitis pigmentosa，RP）患者5例（5只眼）和5例健康人5只眼（5只眼）的视网膜血流速度进行了临床观察。我们使用随机选择的RP患者的眼睛，并使用混合线性模型将其结果与正常受试者进行比较，校正心率，年龄和性别。（1.7 +/- 0.35 cm/s vs 3.0 +/- 0.35 cm/s; P < 0.001）和宽视网膜静脉（1.5 +/- 0.35 cm/s对3.1 +/- 0.30 cm/s; P < 0.001）在研究组中显著低于对照组（未校正心率、年龄或性别）。相应地，研究组的动脉血流速度明显低于对照组，因为动脉血管狭窄（2.3 +/- 0.55 vs 4.2 +/- 0.5; P = 0.006）和宽视网膜动脉（2.5 ± 1.05 cm/s vs4.8 ± 1.0 cm/s; P < 0.001）。视网膜功能成像技术显示视网膜色素变性患者视网膜小血管和大血管的血流速度明显低于健康人。这与视网膜色素变性患者眼底镜检查时观察到的视网膜血管直径的已知减小相对应。视网膜功能成像技术有望用于测量视网膜血流参数。
To measure the retinal blood flow velocity in patients with retinitis pigmentosa using the retinal function imaging technique.The clinical observational investigation included a study group of five eyes of five patients (age: 55.7 +/- 8.6 years) with retinitis pigmentosa (RP) and a control group of five eyes of five healthy subjects. We used a randomly chosen eye of the RP patients, and compared its results to the normal subjects using a mixed linear model, correcting for heart rate, age, and gender.The mean blood velocity in the narrow retinal veins (1.7 +/- 0.35 cm/s versus 3.0 +/- 0.35 cm/s; P < 0.001) and wide retinal veins (1.5 +/- 0.35 cm/s versus 3.1 +/- 0.30 cm/s; P < 0.001) was significantly lower in the study group than in the control group not correcting for heart rate, age or gender. Correspondingly, the arterial blood flow velocity was significantly lower in the study group than in the control group for the narrow arterial vessels (2.3 +/- 0.55 versus 4.2 +/- 0.5; P = 0.006) and for the wide retinal arteries (2.5 +/- 1.05 cm/s versus 4.8 +/- 1.0 cm/s; P < 0.001).Using the retinal function imaging technology revealed significantly lower retinal blood flow velocities in the small and large retinal vessels in patients with retinitis pigmentosa than in healthy subjects. This corresponds with the known decrease in the retinal vessel diameters as observed upon ophthalmoscopy in patients with retinitis pigmentosa. Retinal function imaging technology may hold promise for measurements of retinal blood flow parameters.