Regulatory potential of fever-range whole body hyperthermia on Langerhans cells and lymphocytes in an antigen-dependent cellular immune response
Regulatory potential of fever-range whole body hyperthermia on Langerhans cells and lymphocytes in an antigen-dependent cellular immune response
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DOI：
10.4049/jimmunol.167.5.2666
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发表时间：
2001-09-01
影响因子：
4.4
通讯作者：
Repasky, EA
中科院分区：
文献类型：
--
作者：
Ostberg, JR;Gellin, C;Repasky, EA
发热反应是感染和炎症最常见的特征之一。然而，在实验免疫学研究中，温度很少是一个变量。为了确定热微环境是否具有任何免疫调节潜力的银依赖性反应，我们应用了轻度发热范围的全身热疗（FR-WBH）协议的BALB/c小鼠经历接触性超敏反应（CHS）。我们观察到，相对于CHS反应的不同阶段，FR-WBH治疗的时机对结果至关重要。在用0.5%FITC溶液致敏之前进行FR-WBH处理导致CHS反应降低。这似乎是由于FR-WBH对表皮朗格汉斯细胞运输至引流淋巴结的直接影响。相比之下，在应用诱导剂量的FITC溶液后直接应用FR-WBH导致增强的反应。这一结果与淋巴细胞归巢到激发位点的增加相关。总体而言，这些数据对于感染期间经历的热变化的作用以及相对于免疫治疗策略的FR-WBH的临床使用具有重要意义。
The febrile response is one of the most common features of infection and inflammation. However, temperature is rarely a variable in experimental immunological investigations. To determine whether the thermal microenvironment has any immunoregulatory potential in an Ag-dependent response, we applied a mild fever-range whole body hyperthermia (FR-WBH) protocol to BALB/c mice experiencing the contact hypersensitivity (CHS) reaction. We observed that the timing of this FR-WBH treatment relative to the different phases of the CHS response was crucial to the outcome. FR-WBH treatment before sensitization with a 0.5% FITC solution resulted in a depressed CHS response. This appears to be due to direct effects of FR-WBH on epidermal Langerhans cell trafficking to the draining lymph nodes. In contrast, application of FR-WBH directly after application of the elicitation dose of FITC solution resulted in an enhanced reaction. This result correlates with increased homing of lymphocytes to the site of elicitation. Overall, these data have important implications regarding the role of thermal changes experienced during infection and the clinical use of FR-WBH relative to immunotherapeutic strategies.