Incidence and survival time trends for Spanish children and adolescents with leukaemia from 1983 to 2007
Incidence and survival time trends for Spanish children and adolescents with leukaemia from 1983 to 2007
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DOI：
10.1007/s12094-016-1531-z
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发表时间：
2017-03-01
影响因子：
3.4
通讯作者：
Peris-Bonet, R.
中科院分区：
文献类型：
--
作者：
Marcos-Gragera, R.;Galceran, J.;Peris-Bonet, R.
我们分析了1983- 2007年期间在西班牙基于人群的癌症登记处登记的儿童和青少年白血病的发病率和生存趋势。儿童和青少年白血病病例来自11个西班牙基于人群的癌症登记处。对于生存率，纳入了1991-2005年期间和随访至2010年12月31日的登记研究数据。使用联合点分析评估了总体发病率趋势。使用Kaplan-Meier估计观察到的生存率，并使用对数秩检验检验趋势。基于2606例病例（2274例儿童和332例青少年），白血病的总体年龄校正发病率（ASR w）为儿童47.9例/百万儿童年，青少年23.8例/百万儿童年。白血病的ASRw以9.6%（95%CI：2.2-17.6）的年百分比变化增加，直至1990年，随后比率稳定。在青少年中，发病率没有增加。五年生存率从1991-1995年的66%上升到2001-2005年的76%。按年龄划分，婴儿（0）和青少年（15-19）的存活率明显低于其他年龄组，且未观察到改善。在儿童和青少年中，白血病主要亚组之间的5年生存率差异显著，研究期间观察到的儿童白血病发病率增加趋势仅限于研究初期。在西班牙白血病儿童中观察到生存率的显著改善。然而，在婴儿和青少年中并未观察到这种改善。
We have analysed incidence and survival trends of children and adolescents with leukaemia registered in Spanish population-based cancer registries during the period 1983-2007.Childhood and adolescent leukaemia cases were drawn from the 11 Spanish population-based cancer registries. For survival, registries with data for the period 1991-2005 and follow-up until 31-12-2010 were included. Overall incidence trends were evaluated using joinpoint analysis. Observed survival rates were estimated using Kaplan-Meier, and trends were tested using the log-rank test.Based on 2606 cases (2274 children and 332 adolescents), the overall age-adjusted incidence rate (ASRw) of leukaemia was 47.9 cases per million child-years in children and 23.8 in adolescents. The ASRw of leukaemia increased with an annual percentage change of 9.6 % (95 % CI: 2.2-17.6) until 1990 followed by a stabilisation of rates. In adolescents, incidence did not increase. Five-year survival increased from 66 % in 1991-1995 to 76 % in 2001-2005. By age, survival was dramatically lower in infants (0) and adolescents (15-19) than in the other age groups and no improvement was observed. In both children and adolescents, differences in 5-year survival rates among major subgroups of leukaemias were significant.The increasing incidence trends observed in childhood leukaemias during the study period were confined to the beginning of the period. Remarkable improvements in survival have been observed in Spanish children with leukaemias. However, this improvement was not observed in infants and adolescents.