Enhanced Synaptic Integration of Adult-Born Neurons in the Olfactory Bulb of Lactating Mothers
Enhanced Synaptic Integration of Adult-Born Neurons in the Olfactory Bulb of Lactating Mothers
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DOI：
10.1523/jneurosci.6354-11.2012
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发表时间：
2012-05-30
影响因子：
5.3
通讯作者：
Mizrahi, Adi
中科院分区：
文献类型：
--
作者：
Kopel, Hagit;Schechtman, Eitan;Mizrahi, Adi
成年哺乳动物一生中最戏剧性的事件之一是向母性的转变。这种转变伴随着母亲所表现出的特定的母性行为，这些行为确保了她的后代的生存和福祉。这些行为的执行很可能伴随着特定神经回路的可塑性变化，但这些变化仍然很难定义。在这项工作中，我们研究了哺乳动物嗅球（OB），这已被证明是一个重要的大脑区域的母性行为在小鼠。在OB中，我们专注于成年出生的神经元，这些神经元在成年期间不断纳入回路，从而为分娩后的可塑性提高提供了潜在的基质。我们分析了成年出生的颗粒细胞（abGCs）的动力学和形态学特征，支配OB的经产哺乳期母亲，分娩后不久，以及在幼稚的女性。abGCs的体内延时成像显示，哺乳期母亲的树突棘比未经历过的处女的树突棘明显更稳定。相反，脊柱稳定性的居民GC分娩后保持不变。此外，虽然abGC的棘大小分布在母亲和幼稚处女之间大致相似，但哺乳期母亲的abGC棘密度较低，其突触前组分的密度较高。这些结构特征表明，成年出生的神经元整合到哺乳期母亲的延髓电路增强。这种增强的整合可能作为一种细胞机制，支持新妈妈在分娩后的第一天内嗅觉编码的变化。
One of the most dramatic events during the life of adult mammals is the transition into motherhood. This transition is accompanied by specific maternal behaviors, displayed by the mother, that ensure the survival and the well-being of her offspring. The execution of these behaviors is most likely accompanied by plastic changes in specific neuronal circuits, but these are still poorly defined. In this work, we studied the mammalian olfactory bulb (OB), which has been shown to be an essential brain region for maternal behaviors in mice. In the OB, we focused on adult-born neurons, which are continuously incorporated into the circuit during adulthood, thus providing a potential substrate for heightened plasticity after parturition. We analyzed the dynamics and morphological characteristics of adult-born granule cells (abGCs), innervating the OB of primiparous lactating mothers, shortly after parturition as well as in naive females. In vivo time-lapse imaging of abGCs revealed that dendritic spines were significantly more stable in lactating mothers compared with naive virgins. In contrast, spine stability of resident GCs remained unchanged after parturition. In addition, while spine size distribution of abGCs was approximately similar between mothers and naive virgins, the spine density of abGCs was lower in lactating mothers and the density of their presynaptic components was higher. These structural features are indicative of enhanced integration of adult-born neurons into the bulbar circuitry of lactating mothers. This enhanced integration may serve as a cellular mechanism, supporting changes in olfactory coding of new mothers during their first days following parturition.