Winchinines A and B, Two Unusual Monoterpene Indole Alkaloids with a Third Nitrogen Atom from Winchia calophylla.
Winchinines A and B, Two Unusual Monoterpene Indole Alkaloids with a Third Nitrogen Atom from Winchia calophylla.
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DOI：
10.1002/chin.201646221
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发表时间：
2016-10
期刊：
影响因子：
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通讯作者：
Yu-Ting Li;Xian-da Gao;Wei Zhang;Xiao‐Jun Huang;Dong-Mei Zhang;R. Jiang;Lei Wang;Xiao-Qi Zhang;W. Ye
中科院分区：
文献类型：
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作者：
Yu-Ting Li;Xian-da Gao;Wei Zhang;Xiao‐Jun Huang;Dong-Mei Zhang;R. Jiang;Lei Wang;Xiao-Qi Zhang;W. Ye
从 Winchia calophylla 的嫩枝和叶子中分离出两种具有第三个氮原子的新型单萜吲哚生物碱 (MIA)，winchinines A (1) 和 B (2)，以及三种已知的单萜吲哚生物碱 (MIA)。化合物1是第一个具有6/5/6/5/6/5六环系统和恶唑烷酮单元的天然MIA。化合物2是一种前所未有的氰基取代的蜘蛛精型生物碱。通过核磁共振波谱、单晶X射线衍射和电子圆二色性数据分析阐明了它们的绝对构型结构。
Two novel monoterpenoid indole alkaloids (MIAs) with a third nitrogen atom, winchinines A (1) and B (2), along with three known ones (3–5) were isolated from the twigs and leaves of Winchia calophylla. Compound 1 is the first natural MIA possessing a 6/5/6/5/6/5 hexacyclic ring system with an oxazolidinone unit. Compound 2 is an unprecedented cyano-substituted aspidosperma-type alkaloid. Their structures with absolute configurations were elucidated by means of NMR spectroscopy, single crystal X-ray diffraction, and electronic circular dichroism data analyses.