Binding of streptococci of the "mutans" group to type 1 collagen associated with apatitic surfaces.
Binding of streptococci of the "mutans" group to type 1 collagen associated with apatitic surfaces.
复制标题
“变形”组链球菌与磷灰石表面相关的 1 型胶原蛋白的结合。
DOI：
10.1111/j.1399-302x.1990.tb00410.x
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发表时间：
1990
影响因子：
--
通讯作者：
Gibbons,RJ
中科院分区：
文献类型：
--
作者：
Liu,T;Gibbons,RJ
本研究调查了21株变形链球菌与吸附在羟基磷灰石(HA)表面的人I型胶原结合的能力。所有受试的链球菌(血清a型)和鼠链球菌(血清b型)都与胶原处理的透明质酸(C-HA)有很强的结合力，而c型变形链球菌和d型或g型变形链球菌与C-HA的结合很弱或根本不附着，只有变形链球菌OMZ-175(f型)和B14(e型)与C-HA有明显结合。绑定OFS。板球运动和。RattusLB1对C-HA的作用呈剂量依赖关系，并具有特异性，因为它可被可溶性胶原抑制，但不受卵白蛋白、人纤维蛋白原或纤维连接蛋白的抑制。结合最大值发生在pH 6和8之间，不受所测试的几种糖中任何一种的影响。胰酶处理对链球菌几乎没有影响，但在100℃加热会降低它们与C-HA的结合能力。
The present study surveyed the ability of 21 strains of cariogenic streptococci of the “mutans” group to bind to human type 1 collagen adsorbed on hydroxyapatite (HA) surfaces. All strains ofStreptococcus cricetus(serotype a) andStreptococcus rattus(serotype b) tested attached strongly to collagen‐treated HA (C‐HA).Streptococcus mutansstrains of serotype c andStreptococcus sobrinusstrains of serotype d or g attached poorly, or not at all, to C‐HA.S. mutansstrains OMZ‐175 (serotype f) and B14 (serotype e) were exceptions which exhibited significant binding to C‐HA. Binding ofS. cricetusAHT andS. rattusLB‐1 to C‐HA occurred in a dose‐dependent manner, and was specific since it was inhibited by the presence of soluble collagen, but not by egg albumin, or by human fibrinogen or fibronectin. Binding occurred maximally between pH 6 and 8 and was not affected by any of several sugars tested. Trypsin treatment the streptococci had little affect, but heating at 100°C reduced their ability to bind to C‐HA.