Inorganic nanoparticles kill Toxoplasma gondii via changes in redox status and mitochondrial membrane potential.
Inorganic nanoparticles kill Toxoplasma gondii via changes in redox status and mitochondrial membrane potential.
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DOI：
10.2147/ijn.s122178
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发表时间：
2017
影响因子：
8
通讯作者：
Kato K
中科院分区：
文献类型：
--
作者：
Adeyemi OS;Murata Y;Sugi T;Kato K
本研究评价了金、银和铂纳米颗粒（NPs）的抗弓形虫潜力。筛选无机NP（0.01- 1，000 µg/mL）的抗寄生虫活性。NPs对T.金、银和铂纳米粒的EC 50值分别为≤7、≤1和≤100 µg/mL。在有效的抗T抗体水平下，纳米粒没有显示出宿主细胞的细胞毒性。弓形虫浓度;估计的选择性指数显示对寄生虫的活性是宿主细胞的活性的20倍。反T可能与氧化还原信号传导有关的NPs的弓形虫活性影响寄生虫线粒体膜电位和寄生虫入侵、复制、恢复和感染潜力。我们的研究结果证明了纳米颗粒的抗寄生虫潜力。研究结果支持进一步探索NPs作为替代和有效抗T的可能来源。弓形虫
This study evaluated the anti-Toxoplasma gondii potential of gold, silver, and platinum nanoparticles (NPs). Inorganic NPs (0.01–1,000 µg/mL) were screened for antiparasitic activity. The NPs caused >90% inhibition of T. gondii growth with EC50 values of ≤7, ≤1, and ≤100 µg/mL for gold, silver, and platinum NPs, respectively. The NPs showed no host cell cytotoxicity at the effective anti-T. gondii concentrations; the estimated selectivity index revealed a ≥20-fold activity toward the parasite versus the host cell. The anti-T. gondii activity of the NPs, which may be linked to redox signaling, affected the parasite mitochondrial membrane potential and parasite invasion, replication, recovery, and infectivity potential. Our results demonstrated the antiparasitic potential of NPs. The findings support the further exploration of NPs as a possible source of alternative and effective anti-T. gondii agents.