Coding of Repetitive Transients by Auditory Cortex on Heschl's Gyrus
Coding of Repetitive Transients by Auditory Cortex on Heschl's Gyrus
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DOI：
10.1152/jn.91346.2008
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发表时间：
2009-10-01
影响因子：
2.5
通讯作者：
Howard, Matthew A., III
中科院分区：
文献类型：
--
作者：
Brugge, John F.;Nourski, Kirill V.;Howard, Matthew A., III
Brugge JF，Nourski KV，Oya H，Reale RA，川崎H，Steinschneider M，霍华德MA. Heschl's gyrus听觉皮层对重复瞬变的编码。J Neurophysiol 102：2358-2374，2009.首次发表于2009年8月12日; doi：10.1152/jn.91346.2008。在接受药物难治性癫痫手术评估的人类患者中，研究了Heschl's gyrus（HG）听觉皮层编码重复瞬变的能力。在HG的灰质中慢性植入多触点深度电极。双边提出的刺激点击列车不同的速率从4到200赫兹。平均诱发电位（AEPs）和事件相关频带功率（ERBP），计算在每个14个记录站点的响应，确定了两个听觉领域。占据后内侧HG的核心场的特征在于稳健的多相AEP，其上可以叠加频率跟随响应（FFR）。血流储备分数在低于50 Hz的点击率时显著，随着点击率的增加而迅速下降，但在高达200 Hz的点击率时可以可靠地检测到。这些数据是惊人的相似，由其他人在猴子基本上相同的刺激条件下获得的，这表明在听觉核心的时间处理的机制可能是高度保守的灵长类动物物种。ERBP反映了给定频带内锁相和非锁相功率的增加或减少，在高达250 Hz的伽马频带频率中显示出刺激相关的增加。在核心前外侧的带状场中记录的AEP通常具有低振幅，即使在使用的最低点击率下，也几乎没有或没有短潜伏期波或FFR的证据。从ERBP中提取的响应的非锁相分量显示出在响应于该系列中的最高点击率时发生的鲁棒的长延迟响应。
Brugge JF, Nourski KV, Oya H, Reale RA, Kawasaki H, Steinschneider M, Howard MA. Coding of repetitive transients by auditory cortex on Heschl's gyrus. J Neurophysiol 102: 2358-2374, 2009. First published August 12, 2009; doi:10.1152/jn.91346.2008. The capacity of auditory cortex on Heschl's gyrus (HG) to encode repetitive transients was studied in human patients undergoing surgical evaluation for medically intractable epilepsy. Multicontact depth electrodes were chronically implanted in gray matter of HG. Bilaterally presented stimuli were click trains varying in rate from 4 to 200 Hz. Averaged evoked potentials (AEPs) and event-related band power (ERBP), computed from responses at each of 14 recording sites, identified two auditory fields. A core field, which occupies posteromedial HG, was characterized by a robust polyphasic AEP on which could be superimposed a frequency following response (FFR). The FFR was prominent at click rates below similar to 50 Hz, decreased rapidly as click rate was increased, but could reliably be detected at click rates as high as 200 Hz. These data are strikingly similar to those obtained by others in the monkey under essentially the same stimulus conditions, indicating that mechanisms underlying temporal processing in the auditory core may be highly conserved across primate species. ERBP, which reflects increases or decreases of both phase-locked and non-phase-locked power within given frequency bands, showed stimulus-related increases in gamma band frequencies as high as 250 Hz. The AEPs recorded in a belt field anterolateral to the core were typically of low amplitude, showing little or no evidence of short-latency waves or an FFR, even at the lowest click rates used. The non-phase-locked component of the response extracted from the ERBP showed a robust, long-latency response occurring here in response to the highest click rates in the series.