Hepatitis C-related hepatocellular carcinoma in the United States: Influence of ethnic status
Hepatitis C-related hepatocellular carcinoma in the United States: Influence of ethnic status
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DOI：
10.1111/j.1572-0241.2003.t01-1-07641.x
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发表时间：
2003-09-01
影响因子：
9.8
通讯作者：
Befeler, AS
中科院分区：
文献类型：
--
作者：
Di Bisceglie, AM;Lyra, AC;Befeler, AS
目的：肝细胞癌在美国的发病率呈上升趋势，其发病率和病因在美国不同种族和民族之间有很大的差异。本研究的目的是评估种族和民族状况对美国肝细胞癌病毒病因学的影响。方法：在美国的肝移植中心进行回顾性调查。受访者被要求回顾1997年7月至1999年6月期间在他们机构就诊的所有肝癌患者的图表，并提供关于病例的种族和民族分布以及他们的乙肝和丙型肝炎标志物的血清学状态的信息。结果：构成这项研究基础的691名患者的完整信息可用，其中59%是白人，14%是黑人，16%是亚洲人，11%是其他种族。其中，乙肝表面抗原阳性107例(15.4%)，丙型肝炎病毒抗体阳性322例(46.5%)，两种标志物均阳性33例(4.7%)，均无标志物阳性229例(33.1%)。各种族群体之间存在明显的差异。抗-丙型肝炎病毒阳性是黑人和白人中最常见的危险因素，而乙肝表面抗原阳性是亚洲人肝细胞癌最常见的病因因素。结论：在美国，丙型肝炎病毒感染似乎是肝细胞癌的主要危险因素，特别是在白人和黑人中，而在亚裔患者中，乙肝病毒感染仍然是主要危险因素。这些初步发现表明，需要对肝细胞癌发病机制中的种族差异进行更详细的研究。(C)2003年至上午科尔。胃肠病学的研究。
OBJECTIVES: The incidence of hepatocellular carcinoma (HCC) seems to be rising in the United States (US), and considerable variability in the incidence and etiology of HCC has been noted among different racial and ethnic groups in this country. The aim of this study was to evaluate the influence of racial and ethnic status in the viral etiology of HCC in the US.METHODS: Retrospective surveys were conducted at liver transplantation centers in the US. Respondents were asked to review the charts of all patients with HCC seen at their institution for the 2-yr period between July, 1997, and June, 1999, and provide information about the racial and ethnic distribution of cases and their serological status with regard to hepatitis B and C markers.RESULTS: Complete information was available on 691 patients who formed the basis of this study, comprising 59% whites, 14% blacks, 16% Asians, and 11% other racial groups. Of the patients, 107 patients (15.4%) were positive for hepatitis B surface antigen (HBsAg), 322 had antibodies to hepatitis C virus (anti-HCV) (46.5%), 33 (4.7%) had both HBsAg and anti-HCV), and 229 (33.1%) had neither marker present. Clear differences were seen among racial groups. Anti-HCV positivity was the most frequent risk factor in both blacks and whites, whereas HBsAg positivity was the most frequent etiological factor in Asians with HCC.CONCLUSIONS: HCV infection seems to be the major risk factor for HCC in the US, particularly among individuals of white and black ethnicity, whereas hepatitis B remains the main risk factor among patients of Asian ethnicity. These preliminary findings indicate the need for a more detailed study of ethnic variability in the pathogenesis of HCC. (C) 2003 by Am. Coll. of Gastroenterology.