Curcumin and muscle wasting: a new role for an old drug?
Curcumin and muscle wasting: a new role for an old drug?
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DOI：
10.1016/j.nut.2008.09.002
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发表时间：
2009-02
期刊：
影响因子：
--
通讯作者：
Hasselgren PO
中科院分区：
文献类型：
--
作者：
Alamdari N;O'Neal P;Hasselgren PO
败血症、严重损伤和癌症都与肌肉质量损失有关。这些情况下的肌肉萎缩主要是由蛋白水解增加引起的，至少部分是由 NF-kB 调节的。尽管最近在对肌肉萎缩相关介质和机制的理解方面取得了进展，但仍然缺乏可以预防或逆转肌肉萎缩的有效且普遍接受的治疗方法。在这里，我们回顾了最近的证据，表明姜黄素（二阿魏酰甲烷）是香料姜黄的一种成分，可以防止败血症和内毒素血症期间的肌肉质量损失，并可以刺激外伤后的肌肉再生。几个世纪以来，姜黄素一直是亚洲传统药物的一部分，主要是因为它的抗炎特性。研究表明，抑制 NF-kB 是姜黄素发挥抗炎作用的机制之一。姜黄素易于获取、价格低廉，即使在高剂量下也无毒，因此可能为肌肉萎缩和损伤提供重要的治疗方式。但值得注意的是，姜黄素的肌肉保护作用尚未得到普遍认可，因此需要更多的研究来进一步检验姜黄素在预防和治疗肌肉萎缩中的作用。
Sepsis, severe injury, and cancer are associated with loss of muscle mass. Muscle wasting in these conditions is mainly caused by increased proteolysis, at least in part regulated by NF-kB. Despite recent progress in the understanding of mediators and mechanisms involved in muscle wasting, effective and universally accepted treatments by which muscle atrophy can be prevented or reversed are still lacking. Here, we review recent evidence suggesting that curcumin (diferuloylmethane), a component of the spice turmeric, may prevent loss of muscle mass during sepsis and endotoxemia and may stimulate muscle regeneration after traumatic injury. Curcumin has been part of the traditional Asian medicine for centuries, mainly because of its anti-inflammatory properties. Studies suggest that inhibition of NF-kB is one of the mechanisms by which curcumin exerts its ant-inflammatory effects. Curcumin is easily accessible, inexpensive, and non-toxic even at high doses, and may therefore offer an important treatment modality in muscle wasting and injury. It should be noted, however, that the muscle-sparing effects of curcumin are not universally accepted, and more studies are therefore needed to further test the role of curcumin in the prevention and treatment of muscle wasting.
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