Pharmacokinetics, tissue distribution, excretion, and metabolism of a new cardioprotective agent 10-O-dimethylaminoethylginkgolide B in rats
Pharmacokinetics, tissue distribution, excretion, and metabolism of a new cardioprotective agent 10-O-dimethylaminoethylginkgolide B in rats
复制标题
新型心脏保护剂10-O-二甲氨基乙基银杏内酯B在大鼠体内的药代动力学、组织分布、排泄和代谢
DOI：
10.1080/10286020.2011.620953
复制
发表时间：
2012-01
影响因子：
1.7
通讯作者：
Xie, Lin
中科院分区：
文献类型：
--
作者：
Wang, Guang-Ji;Peng, Dai-Yin;Liu, Xiao-Dong;Zhang, Xian;Chen, Wei-Dong;Liang, Yan;Wang, Xin-Ting;Xie, Tong;Xie, Lin
The plasma pharmacokinetics, tissue distribution, excretion, and metabolism of 10-O-dimethylaminoethylginkgolide B (XQ-1H), a protective agent against cardiovascular accident for its potential anti-platelet-activating factor activity, were investigated in rats. Plasma profiles were obtained after intravenous administration of 4, 8, 16, and 32 mg/kg of XQ-1H. There was a gender difference in the pharmacokinetics of XQ-1H. The elimination half-life of XQ-1H was 209.55, 200.81, 236.95, and 269.78 min in female rats and was 139.63, 173.83, 191.28, and 228.0 min in male rats at doses of 4, 8, 16, and 32 mg/kg, respectively. At four dose levels, female rats have higher values for area under the curve (AUC) than male rats. XQ-1H had linear pharmacokinetic characteristics in rats within the dose ranges tested. The volume of distribution in rats ranged from 6.05 to 15.09 l/kg. XQ-1H showed an extensive distribution into multiple tissues and reached its maximal concentration in all tissues at 10 min post-dose. About 80% of XQ-1H was mainly converted to its hydrolyzed and demethylated metabolites in vivo, and the elimination of unchanged compound was minor ( < 20%) in rats.
登录
查看更多内容
DOI：
10.1007/bf02788536
发表时间：
1995-04
期刊：
International Journal of Pancreatology
影响因子：
--
作者：
Andrzej Dąbrowski;A. Gabryelewicz;L. Chyczewski
通讯作者：
Andrzej Dąbrowski;A. Gabryelewicz;L. Chyczewski
DOI：
10.1007/bf03190627
发表时间：
2005-10-01
影响因子：
1.9
作者：
Liang, Y;Xie, L;Wang, GJ
通讯作者：
Wang, GJ
DOI：
10.1046/j.1440-1681.1999.03146.x
发表时间：
1999-10
影响因子：
2.9
作者：
Shuqing Li;Q. Meng;Lineng Zhang
通讯作者：
Shuqing Li;Q. Meng;Lineng Zhang
影响因子：
16.6
作者：
HANAHAN, DJ
通讯作者：
HANAHAN, DJ
影响因子：
1.7
作者：
Dian-lei Wang;Yan Liang;Lin Xie;Tong Xie;X. Wang;Sen Yu;Guangji Wang;Xiao-dong Liu
通讯作者：
Dian-lei Wang;Yan Liang;Lin Xie;Tong Xie;X. Wang;Sen Yu;Guangji Wang;Xiao-dong Liu