Plasma γ-Glutamyltransferase, Cysteinyl-Glycine, and Oxidized Low-Density Lipoprotein A Pathway Associated With Myocardial Infarction Risk?
Plasma γ-Glutamyltransferase, Cysteinyl-Glycine, and Oxidized Low-Density Lipoprotein A Pathway Associated With Myocardial Infarction Risk?
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DOI：
10.1161/atvbaha.110.209346
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发表时间：
2010-10-01
影响因子：
8.7
通讯作者：
Boeing, Heiner
中科院分区：
文献类型：
--
作者：
Drogan, Dagmar;Weikert, Cornelia;Boeing, Heiner
目的：探讨血浆γ-谷氨酰转移酶（GGT）活性与半胱氨酰甘氨酸（Cys-Gly）（即，源自GGT介导的谷胱甘肽裂解的硫醇），方法和结果-在欧洲癌症和营养前瞻性调查（EPIC）中确定了MI的发病病例-波茨坦受试者在6.0年随访期间无既往MI。在一项病例队列研究中测量了血浆中Cys-Gly和oxLDL和GGT活性的基线水平，该研究包括837例无MI事件的受试者和116例MI事件的受试者。采用考克斯比例风险回归分析评估GGT、Cys-Gly和oxLDL与MI风险的关系。校正已确定的风险因素后，对数转换生物标志物增加1-SD单位相关的风险比分别为GGT 1.63（95% CI，1.30 - 2.05）、Cys-Gly 1.36（95% CI，1.07 - 1.72）和oxLDL 1.37（95% CI，1.00 - 1.86）。Cys-Gly和oxLDL占GGT和MI risk. Conclusion之间的关系的2.3% GGT活性和MI risk.之间的正相关似乎是独立的循环Cys-Gly和oxLDL水平。通过Cys-Gly，我们发现了一种潜在的MI风险新预测因子，其影响需要进一步阐明。（Arterioscler Thromb Vasc Biol.2010; 30：2053-2058.）
Objective-To investigate the interrelation between plasma gamma-glutamyltransferase (GGT) activity, cysteinyl-glycine (Cys-Gly) (ie, a thiol originating from GGT-mediated cleavage of glutathione), and oxidized low-density lipoprotein (oxLDL) with regard to myocardial infarction (MI) risk in a prospective study.Methods and Results-Incident cases of MI were identified among European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam participants without prior MI during 6.0 years of follow-up. Baseline levels of Cys-Gly and oxLDL and GGT activity in plasma were measured in a case-cohort study comprising 837 subjects without incident MI and 116 subjects with incident MI. The relation of GGT, Cys-Gly and oxLDL to MI risk was assessed using Cox proportional hazards regression analysis. After adjustment for established risk factors, hazard ratios associated with a 1-SD unit increase in the log-transformed biomarker were 1.63 (95% CI, 1.30 to 2.05) for GGT, 1.36 (95% CI, 1.07 to 1.72) for Cys-Gly, and 1.37 (95% CI, 1.00 to 1.86) for oxLDL. Cys-Gly and oxLDL accounted for 2.3% of the relation between GGT and MI risk.Conclusion-The positive association between GGT activity and MI risk appears to be independent of circulating Cys-Gly and oxLDL levels. With Cys-Gly, we found a potential new predictor of MI risk whose impact needs to be further elucidated. (Arterioscler Thromb Vasc Biol. 2010; 30: 2053-2058.)