Simultaneous Recordings from the Primary Visual Cortex and Lateral Geniculate Nucleus Reveal Rhythmic Interactions and a Cortical Source for Gamma-Band Oscillations
Simultaneous Recordings from the Primary Visual Cortex and Lateral Geniculate Nucleus Reveal Rhythmic Interactions and a Cortical Source for Gamma-Band Oscillations
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DOI：
10.1523/jneurosci.4216-13.2014
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发表时间：
2014-05-28
影响因子：
5.3
通讯作者：
Usrey, W. Martin
中科院分区：
文献类型：
--
作者：
Bastos, Andre M.;Briggs, Farran;Usrey, W. Martin
神经元活动的振荡同步已经被提出作为调节相互作用的神经元群体之间的有效连接的机制。在视觉系统中，伽马频率范围（30 - 100 Hz）的振荡被认为有助于皮质-皮质通信。为了测试是否有类似的机制可能会影响皮质下-皮质通信，我们记录了局部场电位活动，从视网膜定位对准区域的外侧膝状体核（LGN）和初级视觉皮层（V1）的警觉猕猴观看刺激已知产生强烈的皮质γ-波段振荡。正如预测的那样，我们在V1中发现了强大的伽马波段功率。与此相反，视觉刺激并没有引起γ-波段活动的LGN。有趣的是，对LGN和V1活动的振荡相位同步的分析确定了α（8 - 14 Hz）和β（15 - 30 Hz）频带中的同步。定向连接的进一步分析表明，α-带的相互作用介导的corticogeniculate反馈处理，而β-带的相互作用介导的geniculocortical前馈处理。这些结果表明，虽然LGN和V1显示在较低的频带功能的相互作用，γ-波段活动在警觉的猴子在很大程度上是一个新兴的属性的皮层。
Oscillatory synchronization of neuronal activity has been proposed as a mechanism to modulate effective connectivity between interacting neuronal populations. In the visual system, oscillations in the gamma-frequency range (30-100 Hz) are thought to subserve cortico-cortical communication. To test whether a similar mechanism might influence subcortical-cortical communication, we recorded local field potential activity from retinotopically aligned regions in the lateral geniculate nucleus (LGN) and primary visual cortex (V1) of alert macaque monkeys viewing stimuli known to produce strong cortical gamma-band oscillations. As predicted, we found robust gamma-band power in V1. In contrast, visual stimulation did not evoke gamma-band activity in the LGN. Interestingly, an analysis of oscillatory phase synchronization of LGN and V1 activity identified synchronization in the alpha (8-14 Hz) and beta (15-30 Hz) frequency bands. Further analysis of directed connectivity revealed that alpha-band interactions mediated corticogeniculate feedback processing, whereas beta-band interactions mediated geniculocortical feedforward processing. These results demonstrate that although the LGN and V1 display functional interactions in the lower frequency bands, gamma-band activity in the alert monkey is largely an emergent property of cortex.