One-step preparation method for adamantyl-containing isocyanates, precursors of epoxide hydrolase inhibitors
One-step preparation method for adamantyl-containing isocyanates, precursors of epoxide hydrolase inhibitors
复制标题
DOI：
10.1134/s1070428017050050
复制
发表时间：
2017-05-01
影响因子：
0.8
通讯作者：
Pitushkin, D. A.
中科院分区：
文献类型：
--
作者：
Butov, G. M.;Burmistrov, V. V.;Pitushkin, D. A.
One-step preparation method was developed for adamantyl-containing isocyanates obtained by Curtius reaction from adamantanecarboxylic and acetic acids. Synthesis of isocyanate was performed without the isolation of intermediate acid chloride which solution was added to sodium azide in boiling toluene. In the reactor the acid azide formation and its rearrangement in isocyanate occurred simultaneously. Yields of target products were 83-94% with respect to the acid.
