Inverse relationship of perinatal complications and eye tracking dysfunction in relatives of patients with schizophrenia: evidence for a two-factor model.
Inverse relationship of perinatal complications and eye tracking dysfunction in relatives of patients with schizophrenia: evidence for a two-factor model.
复制标题
精神分裂症患者亲属围产期并发症与眼动追踪功能障碍的负相关：双因素模型的证据。
DOI：
10.1176/ajp.155.7.976
复制
发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Holzman,PS
中科院分区：
文献类型：
--
作者：
Kinney,DK;Levy,DL;Yurgelun-Todd,DA;Tramer,SJ;Holzman,PS
OBJECTIVEBecause both smooth pursuit eye tracking dysfunction and obstetrical complications are significant risk factors for schizophrenia, the authors tested the predictions of a two-factor model of how eye tracking dysfunction and obstetrical complications covary in patients with schizophrenia, their siblings, and comparison subjects.METHODPsychiatric diagnoses, eye tracking dysfunction, and obstetrical complications noted in birth records were independently assessed in 18 patients with schizophrenia, 16 of their siblings without schizophrenia, and 49 comparison subjects with neither personal nor family histories of schizophrenia.RESULTSAs hypothesized, 1) the combination of eye tracking dysfunction and perinatal obstetrical complications discriminated patients with schizophrenia significantly from subjects without schizophrenia, including siblings of patients with schizophrenia, and 2) eye tracking dysfunction and perinatal obstetrical complications manifested a significant inverse association in the nonschizophrenic siblings of patients with schizophrenia.CONCLUSIONSThese results support a two-factor model in which obstetrical complications often interact with genetic liability, indicated by eye tracking dysfunction, to produce schizophrenia.(Am J Psychiatry 1998; 155:976–978)
