Adaptation of high-gamma responses in human auditory association cortex
Adaptation of high-gamma responses in human auditory association cortex
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DOI：
10.1152/jn.00207.2014
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发表时间：
2014-11-01
影响因子：
2.5
通讯作者：
Boatman-Reich, Dana
中科院分区：
文献类型：
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作者：
Eliades, Steven J.;Crone, Nathan E.;Boatman-Reich, Dana
本研究探讨了高频皮层反应的适应性[> 60 Hz；人类非初级听觉皮层中简单和复杂声音的高伽马（HG）。我们使用颅内皮质电图记录来测量事件相关的HG功率变化作为刺激概率的函数。声调和语音刺激以一系列传统的古怪范式和控制范式呈现。我们假设在听觉关联皮层中，随着刺激在多个并发时间尺度上的重复，HG功率会衰减。进行时频分析以确定听觉反应部位。然后使用单试验分析和定量建模来测量高（频繁）、低（不频繁）和等（对照）刺激概率下HG功率的试验间变化。结果显示，HG对频繁重复的音调和言语的反应明显减少，而对不频繁和等概率刺激的反应没有差异。HG频率响应的适应性，而不是刺激声差异或偏差检测增强效应，解释了观察到的高频和低频声音的不同响应。HG反应的适应表现为快速开始（少于两个试验），而在连续重复试验之间（2-10秒）和在刺激块中跨试验（类似于7分钟）的适应较慢。听觉诱发的N100反应也表现出与重复相关的适应性，与先前人类头皮和动物单单元记录一致。这些结果表明，人听觉关联皮层的HG反应对简单和复杂听觉事件的规律性高度敏感，并在多个并发时间尺度上表现出适应性。
This study investigates adaptation of high-frequency cortical responses [> 60 Hz; high-gamma (HG)] to simple and complex sounds in human nonprimary auditory cortex. We used intracranial electrocorticographic recordings to measure event-related changes in HG power as a function of stimulus probability. Tone and speech stimuli were presented in a series of traditional oddball and control paradigms. We hypothesized that HG power attenuates with stimulus repetition over multiple concurrent time scales in auditory association cortex. Time-frequency analyses were performed to identify auditory-responsive sites. Single-trial analyses and quantitative modeling were then used to measure trial-to-trial changes in HG power for high (frequent), low (infrequent), and equal (control) stimulus probabilities. Results show strong reduction of HG responses to frequently repeated tones and speech, with no differences in responses to infrequent and equal-probability stimuli. Adaptation of the HG frequent response, and not stimulus-acoustic differences or deviance-detection enhancement effects, accounted for the differential responses observed for frequent and infrequent sounds. Adaptation of HG responses showed a rapid onset (less than two trials) with slower adaptation between consecutive, repeated trials (2-10 s) and across trials in a stimulus block (similar to 7 min). The auditory-evoked N100 response also showed repetition-related adaptation, consistent with previous human scalp and animal single-unit recordings. These findings indicate that HG responses are highly sensitive to the regularities of simple and complex auditory events and show adaptation on multiple concurrent time scales in human auditory association cortex.