CHOLINERGIC URTICARIA - A CLINICAL AND HISTOLOGIC-STUDY
CHOLINERGIC URTICARIA - A CLINICAL AND HISTOLOGIC-STUDY
复制标题
DOI：
10.1001/archderm.123.4.462
复制
发表时间：
1987-04-01
影响因子：
--
通讯作者：
GREAVES, MW
中科院分区：
文献类型：
--
作者：
HIRSCHMANN, JV;LAWLOR, F;GREAVES, MW
我们研究了35例胆碱能性荨麻疹患者的自然病史、特应性的患病率和发作期间全身症状的频率，7例患者（20%）皮疹的组织学状况，以及18例患者（51%）对乙酰胆碱、组胺和乙酰甲胆碱皮内注射的反应。在大多数患者中，症状开始于10至30岁之间，持续多年，并导致他们改变活动以避免运动，情绪和热量等刺激因素。病情通常随着时间的推移而改善，5名患者（14%）自发缓解。特应性，存在于约12（34%）的患者，比一般人群更频繁。全身症状是罕见的攻击期间，患者没有更大的反应比对照组的皮内试验。组织学研究显示，中性粒细胞和周围的皮肤血管的表面乳头状血管壁。
We studied the natural history, the prevalence of atopy, and the frequency of systemic symptoms during attacks in 35 patients with cholinergic urticaria, the histologic condition of the eruption in seven patients (20%), and the response to intradermal injections of acetylcholine, histamine, and methacholine and 18 patients (51%). In most patients symptoms began between the ages of 10 and 30 years, persisted for many years, and caused them to modify their activities to avoid the provoking factors of exercise, emotion, and heat. The condition usually improved with time, and five patients (14%) had a spontaneous remission. Atopy, present in about 12 (34%) of the patients, was more frequent than in the general population. Systemic symptoms were uncommon during attacks, and patients had no greater responses than controls to the intradermal tests. The histologic study revealed neutrophils in and around the walls of superficial subpapillary dermal vessels.