Comparison of chest radiograph scoring to lung weight as a quantitative index of pulmonary edema in organ donors
Comparison of chest radiograph scoring to lung weight as a quantitative index of pulmonary edema in organ donors
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DOI：
10.1111/j.1399-0012.2011.01591.x
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发表时间：
2012-09-01
影响因子：
2.1
通讯作者：
Matthay, Michael A.
中科院分区：
文献类型：
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作者：
Ware, Lorraine B.;Neyrinck, Arne;Matthay, Michael A.
Ware LB、Neyrinck A、ONeal HR、Lee JW、Landeck M、Johnson E、Calfee CS、Matthay MA 和加州移植捐赠者网络。胸片评分与肺重量作为器官捐献者肺水肿定量指标的比较。摘要：量化器官捐献者的肺水肿程度有助于评估肺水肿的临床严重程度、确定对治疗的反应以及作为治疗试验的终点。目前尚无准确的无创方法来评估肺水肿的程度。我们测试了四象限胸部放射学评分系统的性能，并与 84 名肺未用于移植的供体的肺水肿量化（通过切除肺重量进行量化）进行比较。在器官获取前 3.6 +/- 3.0 小时拍摄胸部 X 光片，并由两位作者进行评分。在没有灌注的情况下切除肺并单独称重。胸部放射学评分系统具有良好的性能：放射学总评分与肺总重量之间的相关性为0.61，p < 0.001。当排除肺不张的胸片时，评分系统的性能得到改善（r = 0.79，p < 0.001）。检测中度肺水肿（肺总重> 1000 g）的受试者工作特征曲线下面积为0.80。该胸部放射照相评分系统可能用于评估肺水肿的临床严重程度，并且可能有助于评估供体是否适合肺移植。
Ware LB, Neyrinck A, ONeal HR, Lee JW, Landeck M, Johnson E, Calfee CS, Matthay MA and the California Transplant Donor Network. Comparison of chest radiograph scoring to lung weight as a quantitative index of pulmonary edema in organ donors. Abstract: Quantification of the degree of pulmonary edema in organ donors is useful for assessing the clinical severity of pulmonary edema, determining response to therapy, and as an endpoint for therapeutic trials. Currently, there is no accurate non-invasive method for assessing the degree of pulmonary edema. We tested the performance of a four-quadrant chest radiographic scoring system compared to quantification of pulmonary edema by excised lung weight in 84 donors whose lungs were not used for transplantation. Chest radiographs were taken 3.6 +/- 3.0 h prior to organ procurement and were scored by two of the authors. Lungs were excised without perfusion and individually weighed. The chest radiographic scoring system had good performance: correlation between total radiographic score and total lung weight of 0.61, p < 0.001. Performance of the scoring system was improved when chest radiographs with atelectasis were excluded (r = 0.79, p < 0.001). The area under the receiver operator characteristic curve for the detection of moderate pulmonary edema (total lung weight >1000 g) was 0.80. This chest radiographic scoring system may potentially be used to assess the clinical severity of pulmonary edema and may be useful as part of the evaluation of donors for suitability for lung transplantation.