Distinct serumal proteomic patterns between ascending and descending types of loco-regionally advanced nasopharyngeal carcinoma assessed by surface enhanced laser desorption ionization and artificial neural network analyses.
Distinct serumal proteomic patterns between ascending and descending types of loco-regionally advanced nasopharyngeal carcinoma assessed by surface enhanced laser desorption ionization and artificial neural network analyses.
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发表时间：
2005-11
影响因子：
6.1
通讯作者：
Xiang Guo;S. Cao;Jiekai Yu;M. Hong;Chang-qing Zhang;Ning-wei Li;Yan-Qun Xiang;C. Qian;Xun Hu;H. Min;Y. Zeng
中科院分区：
文献类型：
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作者：
Xiang Guo;S. Cao;Jiekai Yu;M. Hong;Chang-qing Zhang;Ning-wei Li;Yan-Qun Xiang;C. Qian;Xun Hu;H. Min;Y. Zeng
鼻咽癌（NPC）在大多数国家是罕见的，特别是在欧洲和北美（发病率低于1/10万人/年）。然而，它在中国南方的几个地区有很高的发病率，特别是在广东地区，包括广州市，其发病率约为每年30-80/10万人。1在高发地区，95%以上的NPC是低分化的（WHO 2型和3型），对放疗和化疗敏感。鼻咽癌除了具有特殊的流行病学和病理学特征外，还具有不同于其他头颈部肿瘤的独特的临床发展特点。晚期NPC可分为三种临床类型：（1）颅型（A型或升型），肿瘤直接向颅底延伸，累及Ⅰ、Ⅲ、Ⅳ、Ⅴ1、Ⅵ颅神经和/或骨质破坏，但无颈部淋巴结肿大;（B）全身性颈淋巴结肿大型D型（下行型）的特点是单侧或双侧颈淋巴结广泛转移，肿块大小为8 cm×8 cm，但不累及颅神经（42.2%）;（c）混合型（AD或升降型）显示了上述两种类型的特征，颈部淋巴结肿大多为长期局限性病变，肿块达8 cm×8 cm者较少（30.0%）。A型和D型患者的代表性示例如图1所示。不同的临床亚群有不同的生物学行为，不同的治疗结果，需要不同的治疗方案。因此，明确NPC的临床分型有助于制定个体化治疗方案。
Nasopharyngeal carcinoma (NPC) is rare in most countries,especially in Europe and North America (incidence rate below 1/100 000 people per year). However, it has a high incidence in several southern areas in China, especially in the Cantonese region, including Guangzhou city, where the incidence rate is approximately 30-80/100 000 people per year.1 In the high incidence areas, more than 95% NPCs are poorly differentiated (WHO types 2 and 3), which are sensitive to radiotherapy and chemotherapy. Besides its special epidemiological and pathological characteristics, NPC differs from other head and neck cancers in terms of its unique clinical development features. The advanced NPCs can be divided into three clinical types:2 (a) cranial type (A or ascending type) is characterized by direct extension of the tumor toward the base of skull with involvement of the cranial nerves Ⅰ, Ⅲ, Ⅳ, Ⅴ1 and Ⅵ and/or destruction of the bone, but without cervical lymphadenopathy. About 12.4% patients belonged to this type; (b) generalized cervical lymphadenopathy type (D or descending type) has the special feature of extensive metastasis in the cervical lymph nodes on one or both sides with a large mass of 8 cm×8 cm, yet without affecting the cranial nerves (42.2%); (c) mixed type (AD or ascending-descending type) shows the features of both the above 2 types, but cervical lymphadenopathy usually remains localized for a long time and the size of the mass rarely reaches 8 cm×8 cm (30.0%). A representative example of type A and type D patients is shown in Fig. 1. Different clinical subsets have different biological behaviors, different treatment outcomes, and deserve different therapeutic plans. Therefore, defining NPC clinical types is useful for the individualized therapeutic planning.