Development and Characterization of Zein-Based Micro Carrier System for Sustained Delivery of Aceclofenac Sodium
Development and Characterization of Zein-Based Micro Carrier System for Sustained Delivery of Aceclofenac Sodium
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DOI：
10.1208/s12249-011-9731-x
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发表时间：
2012-03-01
影响因子：
3.3
通讯作者：
Korrapati, Purna Sai
中科院分区：
文献类型：
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作者：
Karthikeyan, K.;Lakra, Rachita;Korrapati, Purna Sai
非甾体类抗炎药（NSAIDs）长期使用可引起胃损伤。本研究旨在通过将非甾体抗炎药包被玉米蛋白（一种耐酸生物聚合物）来减少其副作用。采用乳化和溶剂蒸发法制备了载乙酰氯芬酸玉米蛋白微球。玉米蛋白微球在胃pH值下的稳定性延缓了被包裹药物的释放，从而降低了胃损伤的可能性。然而，乙酰氯芬酸的体外释放在肠道ph值下可持续长达72小时。因此，玉米蛋白微球为开发安全和持续的非甾体抗炎药递送系统铺平了道路，从而实现了对慢性炎症性疾病的预期治疗潜力，减少了副作用。
Nonsteroidal anti-inflammatory drugs (NSAIDs) induce gastric injury on long-term usage. This study aims at reducing the side effect of NSAIDs by encapsulating in zein, an acid-resistant biopolymer. Aceclofenac-loaded zein microspheres were prepared by emulsification and solvent evaporation method. The stability of zein microspheres at gastric pH retarded the release of the entrapped drug and hence reduces the possibility of gastric injury. However, the in vitro release of aceclofenac was sustained up to 72 h at intestinal pH. Thus, zein microspheres pave the way for the development of safe and sustained delivery system for NSAIDs thereby achieving the desired therapeutic potential with reduced side effects for chronic inflammatory disorders.