Syntactic comprehension deficits in Alzheimer's disease
Syntactic comprehension deficits in Alzheimer's disease
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DOI：
10.1006/brln.1999.2277
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发表时间：
2000-02-15
影响因子：
2.5
通讯作者：
Schröder, J
中科院分区：
文献类型：
--
作者：
Bickel, C;Pantel, J;Schröder, J
研究了德国阿尔茨海默型痴呆患者的句法理解能力，并将其与年龄、性别和教育程度相匹配的健康对照进行了比较。特别注意的是语法结构，与英语等语言相比，这在语法丰富的语言（如德语）中是可行的。在句子图片匹配范式中，只使用语义可逆的句子。句法复杂性从简单的主动语态句到更复杂的句子，如中心嵌入的宾语关系句。与对照组相比，患者在几乎所有类别中都表现出缺陷。他们的表现不受年龄的影响，但受到认知障碍程度的严重影响。轻度认知障碍患者（MMSE评分为20分或更高）在句法处理上仅表现出轻微困难，而中度至重度认知障碍患者（MMSE < 20）在大多数句法类别上的表现均不高于机会限制。似乎句法理解能力在阿尔茨海默病的早期阶段只受到轻微影响，而在晚期阶段则受到相当严重的损害。在本报告中，研究结果讨论了工作记忆对句法处理的需求，(C) 2000学术出版社。
Syntactic comprehension of German patients with dementia of the Alzheimer type was investigated and compared to healthy controls matched with respect to age, sex, and education. Special attention was directed at syntactic structures, which, in contrast to a language like English, are feasible in a grammatically rich language like German. In a sentence picture matching paradigm, only semantically reversible sentences were used. Syntactic complexity ranged from simple active voice sentences to more complex sentences like center-embedded object relative sentences. In comparison to their controls, patients showed a deficit in nearly all categories. Their performance was not influenced by age, but was heavily influenced by the degree of cognitive impairment. Patients with mild cognitive impairment, as defined by a MMSE score of 20 or higher, showed only slight difficulties in syntactic processing, whereas patients with moderate to severe impairment (MMSE < 20) did not perform above chance limits in most syntactic categories. It appears as though syntactic comprehension Is only mildly affected in the early stages of Alzheimer's disease and is rather severely impaired in more advanced stages. In the present report, results are discussed in terms of working memory demands for syntactic processing, (C) 2000 Academic Press.