A computer model of normal conduction in the human atria.
A computer model of normal conduction in the human atria.
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DOI：
10.1161/01.res.87.7.e25
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发表时间：
2000-09
影响因子：
20.1
通讯作者：
Craig S. Henriquez David M. Harrild
中科院分区：
文献类型：
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作者：
Craig S. Henriquez David M. Harrild
虽然在理解人类心房中的波前传播和波前发生的过程方面已经取得了相当大的进展，但技术问题和患者安全问题限制了实验研究。目前的工作描述了一个有限体积为基础的计算机模型的人类心房激活和电流流动，以补充这些研究。与以前的表示不同，该模型是三维的，包括左心房和右心房以及心房的主要肌束，包括界嵴、梳状肌、卵圆窝的利姆布斯和Bachmann束。纤维束被表示为各向异性结构，纤维方向与纤维束轴对齐。将传导率分配给模型，以给出束和大块组织内的真实局部传导速度。模拟结果表明，在正常窦性心律的作用束，也揭示了在隔膜，实验映射一直是极具挑战性的激活模式。为了验证该模型，模拟正常的激活序列和传导速度在不同的位置进行比较与实验观察和数据。该模型也被用来调查起搏激活，和机制的相对延长左与右刺激。由于现实的几何形状和束结构，该模型可用于进一步分析正常的激活序列，并检查异常传导，包括颤振。这篇文章的全文可以在http://www.circresaha.org上找到。
Although considerable progress has been made in understanding the process of wavefront propagation and arrhythmogenesis in human atria, technical concerns and issues of patient safety have limited experimental investigations. The present work describes a finite volume-based computer model of human atrial activation and current flow to complement these studies. Unlike previous representations, the model is three-dimensional, incorporating both the left and right atria and the major muscle bundles of the atria, including the crista terminalis, pectinate muscles, limbus of the fossa ovalis, and Bachmann's bundle. The bundles are represented as anisotropic structures with fiber directions aligned with the bundle axes. Conductivities are assigned to the model to give realistic local conduction velocities within the bundles and bulk tissue. Results from simulations demonstrate the role of the bundles in a normal sinus rhythm and also reveal the patterns of activation in the septum, where experimental mapping has been extremely challenging. To validate the model, the simulated normal activation sequence and conduction velocities at various locations are compared with experimental observations and data. The model is also used to investigate paced activation, and a mechanism of the relative lengthening of left versus right stimulation is presented. Owing to both the realistic geometry and the bundle structures, the model can be used for further analysis of the normal activation sequence and to examine abnormal conduction, including flutter. The full text of this article is available at http://www.circresaha.org.