Application of two‐dimensional gel‐based mass spectrometry to functionally dissect resistance to targeted cancer therapy
Application of two‐dimensional gel‐based mass spectrometry to functionally dissect resistance to targeted cancer therapy
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DOI：
10.1002/prca.201300056
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发表时间：
2013-12
期刊：
影响因子：
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通讯作者：
O. Klein;N. Rohwer;Katja Freitag Molina;S. Mergler;Petra Wessendorf;Marion Herrmann;J. Klose;T. Cramer
中科院分区：
文献类型：
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作者：
O. Klein;N. Rohwer;Katja Freitag Molina;S. Mergler;Petra Wessendorf;Marion Herrmann;J. Klose;T. Cramer
大多数胃癌被诊断为晚期，具有强烈的治疗抵抗力。癌蛋白缺氧诱导因子1(HIF-1)与治疗耐药有关，部分是通过激活DNA损伤反应。我们已经注意到在体外，胃癌细胞在功能上补偿HIF-1丢失的能力很强。这项研究的目的是确定这种补偿背后的分子途径。
The majority of gastric cancers are diagnosed at advanced stages, characterized by robust therapy resistance. The oncoprotein hypoxia‐inducible factor 1 (HIF‐1) is associated with therapy resistance, partly via activation of the DNA damage response. We have noted a robust ability of gastric cancer cells to functionally compensate the loss of HIF‐1 in vitro. The purpose of this study was to identify molecular pathways that underlie this compensation.