Cellular Computations Underlying Detection of Gaps in Sounds and Lateralizing Sound Sources.

Cellular Computations Underlying Detection of Gaps in Sounds and Lateralizing Sound Sources.
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DOI:
10.1016/j.tins.2017.08.001
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发表时间:
2017-10
影响因子:
15.9
通讯作者:
Allen PD
Allen PD
中科院分区:
医学1区
文献类型:
--
作者:
Oertel D;Cao XJ;Ison JR;Allen PD

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In mammals, acoustic information arises in the cochlea and is transmitted to the ventral cochlear nuclei (VCN). Three groups of VNC neurons extract different features from the firing of auditory nerve fibers, and convey that information along separate pathways through the brainstem. Two of these pathways process temporal information: octopus cells detect coincident firing among auditory nerve fibers, and transmit signals along monaural pathways; and bushy cells sharpen the encoding of fine structure and feed binaural pathways. The ability of these cells to signal with temporal precision depends on a low-voltage-activated K+ conductance (gKL) and a hyperpolarization-activated conductance (gh). This ‘tale of two conductances’ traces gap detection and sound lateralization to their cellular and biophysical origins.
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