Cerebrospinal fluid MFG-E8 as a promising biomarker of amyotrophic lateral sclerosis
Cerebrospinal fluid MFG-E8 as a promising biomarker of amyotrophic lateral sclerosis
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脑脊液 MFG-E8 作为肌萎缩侧索硬化症有前景的生物标志物
DOI：
10.1007/s10072-020-04416-3
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发表时间：
2020
影响因子：
3.3
通讯作者：
Shi Xiaolei
中科院分区：
文献类型：
--
作者：
Yang Biying;Wu Yongshun;Wang Yihao;Yang Huili;Du Baoxin;Di Wei;Xu Xiaotian;Shi Xiaolei
肌萎缩侧索硬化症（Amyotrophiclateralsclerosis，ALS）是一种以上、下运动神经元功能障碍为主要表现的神经退行性疾病。液体中的生物标志物已被用于监测疾病及其进展。乳脂球-EGF因子8（MFG-E8）是一种炎症调节因子，参与神经退行性疾病的发病机制。我们在这里采取这项研究，以评估MFG-E8在ALS的预测价值。MethodsThis研究包括19例ALS患者和15名健康对照。从所有参与者中收集脑脊液（CSF），并检测MFG-E8、神经丝轻链（NFL）和重链（NFH）的水平。MFG-E8与NFL，NFH，ALS的严重程度，认知状态，和用力肺活量（FVC）之间的相关性进行了分析。ResultsWe发现，MFG-E8在区分ALS与对照，与相对较高的水平MFG-E8在ALS受试者，比对照。此外，MFG-E8与修订的ALS功能评定量表（ALS-FRS）呈负相关，但与NFL和NFH水平，疾病持续时间，进展率，简易精神状态检查（MMSE），和FVC.ConclusionsThe研究证明，CSF MFG-E8有助于区分ALS从控制。然而，CSF中的蛋白质阴性预测疾病的严重程度。
IntroductionAmyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disease resulting in the dysfunction of upper and lower motor neurons. Biomarkers in fluid have been used to monitor the disease and its progression. Milk fat globule-EGF factor 8 (MFG-E8) is an inflammation modulator, which is involved in the pathogenesis of neurodegenerative diseases. We here took this study to evaluate the predictive value of MFG-E8 in ALS.MethodsThis study consisted of 19 patients with ALS and 15 healthy controls. Cerebrospinal fluid (CSF) were collected from all participants and tested for the levels of MFG-E8, neurofilament light (NFL), and heavy chain (NFH). The correlations between MFG-E8 and NFL, NFH, ALS severity, cognitive status, and forced vital capacity (FVC) were analyzed.ResultsWe found that MFG-E8 performs well in distinguishing ALS from controls, with relatively higher level of MFG-E8 in ALS subjects, than controls. Moreover, MFG-E8 negatively correlated with the revised ALS function rating scale (ALS-FRS), but not with the levels of NFL and NFH, disease duration, progression rate, mini-mental state examination (MMSE), and FVC.ConclusionsThe study proved that CSF MFG-E8 helps distinguish ALS from controls. However, the protein in CSF negatively predicted disease severity.