Discrimination between obesity and insulin resistance in the relationship with adiponectin
Discrimination between obesity and insulin resistance in the relationship with adiponectin
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DOI：
10.2337/diabetes.53.3.585
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发表时间：
2004-03-01
期刊：
影响因子：
7.7
通讯作者：
Reaven, PD
中科院分区：
文献类型：
--
作者：
Abbasi, F;Chu, JW;Reaven, PD
胰岛素抵抗和肥胖都与较低的血浆脂联素浓度有关。由于胰岛素抵抗和肥胖是相关的，脂联素与胰岛素抵抗的联系在多大程度上依赖于它与肥胖的关系尚不清楚。为了解决这个问题，对60名非糖尿病受试者的空腹血浆脂联素浓度进行了测量，根据他们的肥胖程度和胰岛素抵抗程度将他们分成四组。通过测定注射奥曲肽、葡萄糖和胰岛素后的稳态血糖(SSPG)浓度来量化胰岛素抵抗，并通过BMI评估肥胖程度。受试者被定义为肥胖(BMI大于或等于30.0 kg/m(2))或非肥胖(190 mg/dl)。胰岛素抵抗的受试者显著降低(P<；0.001)(平均值+/-SD)。脂联素浓度，无论是肥胖(17.1+/-5.9微克/毫升)还是非肥胖者(16.3+/-7.5微克/毫升)，与肥胖、胰岛素敏感者(34.3+/-13.1微克/毫升)或非肥胖、胰岛素敏感者(29.8+/-15.3微克/毫升)进行比较。最后，胰岛素敏感受试者的脂联素水平变化幅度明显大于胰岛素抵抗受试者。这些结果表明，与肥胖相比，脂联素浓度与胰岛素介导的葡萄糖处置差异的关系更密切。
Insulin resistance and obesity are both associated with lower plasma adiponectin concentrations. Since insulin resistance and obesity are related, the extent to which the association of adiponectin with insulin resistance is dependent on its relationship with obesity is unclear. To address this issue, fasting plasma adiponectin concentrations were measured in 60 nondiabetic subjects, stratified into four equal groups on the basis of both their degree of adiposity and insulin resistance. Insulin resistance was quantified by determining the steady-state plasma glucose (SSPG) concentration in response to an infusion of octreotide, glucose, and insulin, and degree of adiposity was assessed by BMI. Subjects were defined as obese (BMI greater than or equal to30.0 kg/m(2)) or nonobese ( 190 mg/dl). Insulin-resistant subjects had significantly (P < 0.001) lower (mean +/- SD). adiponectin concentrations, whether they were obese (17.1 +/- 5.9 mu g/ml) or nonobese (16.3 +/- 7.5 mu g/ml) as compared with either obese, insulin-sensitive (34.3 +/- 13.1 mu g/ml) or nonobese, insulin-sensitive (29.8 +/- 15.3 mu g/ml) subjects. Finally, adiponectin levels in insulin-sensitive subjects varied to a significantly greater degree than in insulin-resistant subjects. These results suggest that adiponectin concentrations are more closely related to differences in insulin-mediated glucose disposal than obesity.