Normalization of spiroperidol binding in the denervated rat striatum by homologous grafts of substantia nigra.
Normalization of spiroperidol binding in the denervated rat striatum by homologous grafts of substantia nigra.
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通过黑质同源移植物使去神经大鼠纹状体中的螺哌啶醇结合正常化。
DOI：
10.1126/science.6635666
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Wyatt,RJ
中科院分区：
文献类型：
--
作者：
Freed,WJ;Ko,GN;Niehoff,DL;Kuhar,MJ;Hoffer,BJ;Olson,L;Cannon-Spoor,HE;Morihisa,JM;Wyatt,RJ
将胚胎黑质移植到成年大鼠脑中可减少单侧黑质损伤后多巴胺受体超敏性引起的运动不对称性。作者报告说，这种移植效应是黑质移植物特有的。他们还报告说，与运动不对称性的减少相结合，这些移植物导致突触后多巴胺能结合位点恢复到正常密度，如氚化螺哌利多放射自显影术所测量的。因此，在脑损伤的动物中，黑质移植物产生宿主脑细胞受体功能状态的长期改变，这与行为缺陷的减少有关。
Transplantation of embryonic substantia nigra into the adult rat brain decreases the motor asymmetry that is produced by dopamine receptor supersensitivity after a unilateral lesion of the substantia nigra. The authors report that this effect of transplantation is specific to grafts of substantia nigra. They also report that, in conjunction with the decrease in motor asymmetry, these grafts cause postsynaptic dopaminergic binding sites to return to normal density as measured by tritiated spiroperidol autoradiography. Thus, in animals with brain lesions, grafts of substantia nigra produce a long-term alteration in the functional status of host brain cell receptors that is associated with a reduction in the behavioral deficit.