The kinome 'at large' in cancer
The kinome 'at large' in cancer
复制标题
DOI：
10.1038/nrc.2015.18
复制
发表时间：
2016-02-01
影响因子：
78.5
通讯作者：
Daly, Roger J.
中科院分区：
文献类型：
--
作者：
Fleuren, Emmy D. G.;Zhang, Luxi;Daly, Roger J.
在过去的十年中，基因组学、蛋白质组学和功能基因组学技术的快速发展使人们能够深入研究癌症基因组和蛋白质组，并对基因功能进行高通量分析，从而能够表征人类癌症中的激酶组，为蛋白激酶超家族成员如何在恶性肿瘤中失调提供了重要的见解，特定激酶在癌症中的背景依赖性功能作用以及激酶组重构如何调节抗癌药物的敏感性。这些互补方法的力量，以及从中获得的见解，构成了这篇分析文章的基础。
Over the past decade, rapid advances in genomics, proteomics and functional genomics technologies that enable in-depth interrogation of cancer genomes and proteomes and high-throughput analysis of gene function have enabled characterization of the kinome 'at large' in human cancers, providing crucial insights into how members of the protein kinase superfamily are dysregulated in malignancy, the context-dependent functional role of specific kinases in cancer and how kinome remodelling modulates sensitivity to anticancer drugs. The power of these complementary approaches, and the insights gained from them, form the basis of this Analysis article.