Abi1, a critical molecule coordinating actin cytoskeleton reorganization with PI-3 kinase and growth signaling.
Abi1, a critical molecule coordinating actin cytoskeleton reorganization with PI-3 kinase and growth signaling.
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DOI：
10.1016/j.febslet.2012.05.015
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发表时间：
2012-08-14
期刊：
影响因子：
3.5
通讯作者：
Kotula L
中科院分区：
文献类型：
--
作者：
Kotula L
肌动蛋白细胞骨架重组与生长和增殖信号的协调是一个关键的细胞过程，目前还不完全清楚。PI-3激酶是将生长因子受体下游的生长和增殖信号分配到细胞核的中心节点之一。虽然PI-3激酶的功能与肌动蛋白细胞骨架重构有关，但对调节这一调控的机制还缺乏令人满意的解释。我们认为，Abi1蛋白与PI-3激酶P85调节亚基的相互作用代表了生长受体信号与肌动蛋白细胞骨架重塑之间的联系。ABI1的这种涉及波状复合体的功能最初是在巨噬细胞增多症中观察到的，这可能解释了PI-3激酶和肌动蛋白细胞骨架在癌症中的一致失调。
Coordination of actin cytoskeletal reorganization with growth and proliferation signals is a key cellular process that is not fully understood. PI-3 kinase is one of the central nodes for distributing growth and proliferation signals downstream from growth factor receptors to the nucleus. Although PI-3 kinase function has been associated with actin cytoskeleton remodeling, satisfactory explanations of the mechanisms mediating this regulation have been elusive. Here we propose that interaction of the Abi1 protein with the p85 regulatory subunit of PI-3 kinase represents the link between growth receptor signaling and actin cytoskeleton remodeling. This function of Abi1, which involves WAVE complex, was initially observed in macropinocytosis, and may explain the coincident dysregulation of PI-3 kinase and actin cytoskeleton in cancer.