Smoking affects treatment outcome in patients with resected esophageal squamous cell carcinoma who received chemotherapy.
Smoking affects treatment outcome in patients with resected esophageal squamous cell carcinoma who received chemotherapy.
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吸烟影响接受化疗的食管鳞状细胞癌切除患者的治疗结果。
DOI：
10.1371/journal.pone.0123246
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Fu J
中科院分区：
文献类型：
--
作者：
Zheng Y;Cao X;Wen J;Yang H;Luo K;Liu Q;Huang Q;Chen J;Fu J
据报道，吸烟会降低各种癌症患者的生存率并诱导化疗耐药性。然而，吸烟对食管鳞状细胞癌（ESCC）患者的影响仍然未知。从中国南方一家机构回顾性入组了1,084例ESCC患者。根据治疗方式将患者分为两组：SC组（手术+化疗）（n = 306）和S组（手术+化疗）（n = 778）。吸烟状态量化为吸烟史（非吸烟者、既往吸烟者和当前吸烟者）和累积吸烟（0、0 - 20和大于20包-年）。使用Kaplan-Meier方法和单变量/多变量回归分析评估吸烟与总生存期（OS）之间的相关性。在1,084例患者中，702例（64.8%）报告了吸烟史，非吸烟者和吸烟者的5年OS分别为45.8%和37.3%。在SC组中，与非吸烟者相比，既往吸烟者和当前吸烟者的校正HR分别为1.540（95%CI，1.1-2.2）和2.110（95%CI，1.4-3.1）; OS降低与吸烟增加相关（P趋势= 0.001）。这些关联在S组中不显著。在SC组的亚组分析中，年龄、性别、体重指数、饮酒或化疗方法（化疗和放化疗）并未显著改变吸烟导致的OS降低。我们的研究结果表明，吸烟可能会影响接受化疗的ESCC切除患者的治疗结果。
Cigarette smoking is reported to decrease survival and induce chemotherapy resistance in patients with various cancers. However, the impact of cigarette smoking on patients with esophageal squamous cell carcinoma (ESCC) remains unknown. A total of 1,084 ESCC patients were retrospectively enrolled from a southern Chinese institution. Patients were divided into two groups according to their treatment modalities: the SC group (surgery with chemotherapy) (n = 306) and the S group (surgery without chemotherapy) (n = 778). Smoking status was quantified as smoking history (non-smoker, ex-smoker, and current smoker) and cumulative smoking (0, between 0 and 20, and greater than 20 pack-years). The association between cigarette smoking and overall survival (OS) was evaluated using the Kaplan-Meier method and univariate/multivariate regression analysis. Among 1,084 patients, 702 (64.8%) reported a cigarette smoking history, and the 5-year OS for non-smokers and smokers was 45.8% and 37.3%, respectively. In the SC group, compared with non-smoker, the adjusted HRs of ex-smoker and current smoker were 1.540 (95% CI, 1.1–2.2) and 2.110 (95% CI, 1.4–3.1), respectively; there is a correlative trend of decreased OS with increased cigarette smoking (P trend = 0.001). These associations were insignificant in the S group. In subgroup analysis of the SC group, the lower OS conferred by smoking was not significantly modified by age, gender, body mass index, alcohol drinking, or chemotherapy method (chemotherapy and chemoradiotherapy). Our results suggest that smoking may affect treatment outcome in patients with resected ESCC who received chemotherapy.
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DOI：
10.1161/atvbaha.107.159533
发表时间：
2008-04-01
影响因子：
8.7
作者：
Luo, Bai;Soesanto, Yudi;McClain, Donald A.
通讯作者：
McClain, Donald A.
影响因子：
2.4
作者：
Kofoed, S. C.;Muhic, A.;Svendsen, L. B.
通讯作者：
Svendsen, L. B.
影响因子：
45.3
作者：
Allum, William H.;Stenning, Sally P.;Langley, Ruth E.
通讯作者：
Langley, Ruth E.
影响因子：
5.7
作者：
Shitara, Kohei;Matsuo, Keitaro;Tanaka, Hideo
通讯作者：
Tanaka, Hideo
影响因子：
50.5
作者：
FOUNTZILAS, G;KOSMIDIS, P;DANIILIDIS, J
通讯作者：
DANIILIDIS, J