Enantioselective Alkynylation of Isatins: A Combination of Metal Catalysis and Organocatalysis
Enantioselective Alkynylation of Isatins: A Combination of Metal Catalysis and Organocatalysis
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靛红的对映选择性炔基化：金属催化和有机催化的结合
DOI：
10.1002/chem.202003118
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Min Zhang
中科院分区：
文献类型：
--
作者：
Dan Jiang;Pei Tang;Qiuyuan Tan;Zhao Yang;Ling He;Min Zhang
报道了一种高效的靛红不对称炔基化反应，该反应采用双功能氨基膦-脲/AgBF_4络合物为催化剂。通过金属催化和有机催化的结合，实现了优异的对映选择性（高达99%ee）和良好的产率。这种新的催化剂体系可以耐受多种末端炔和靛红，从而高效地获得具有四取代立体中心的结构多样的炔丙醇。
An efficient and catalytic asymmetric alkynylation of isatins has been developed using a bifunctional amidophosphine-urea/AgBF4 complex as the catalyst. By a combination of metal catalysis and organocatalysis, excellent enantioselectivities (up to 99% ee) and good yields are achieved. A wide range of both terminal alkynes and isatins are tolerated by this new catalyst system, providing access to structurally diverse propargylic alcohols with tetrasubstituted.stereogenic centers in high efficiency.