An Investigation on a Novel Anti-tumor Fusion Peptide of FSH33-53-IIKK.
An Investigation on a Novel Anti-tumor Fusion Peptide of FSH33-53-IIKK.
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新型抗肿瘤融合肽FSH33-53-IIKK的研究
DOI：
10.7150/jca.14425
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发表时间：
2016
影响因子：
3.9
通讯作者：
Yang M
中科院分区：
文献类型：
--
作者：
Yang R;Liu P;Pan D;Zhang P;Bai Z;Xu Y;Wang L;Yan J;Yan Y;Liu X;Yang M
A novel fusion peptide FSH33-53-IIKK was designed and expected to combine the follicle stimulating hormone receptor (FSHR) targeting and tumor toxicity. In vitro and in vivo study showed the anti-tumor activity of FSH33-53-IIKK was enhanced compared to that of IIKK only. FSH33-53-IIKK could inhibit the growth of tumor via apoptosis and autophagy pathways. In summary, combining the tumor marker-target peptide and anti-tumor peptide together may be an efficient way to search for better anti-tumor candidates.
