Influence of cadmium chloride, mercuric chloride, and sodium vanadate on the glutathione-conjugating enzyme system in liver, kidney, and brain of mice.
Influence of cadmium chloride, mercuric chloride, and sodium vanadate on the glutathione-conjugating enzyme system in liver, kidney, and brain of mice.
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氯化镉、氯化汞和钒酸钠对小鼠肝、肾和脑中谷胱甘肽结合酶系统的影响。
DOI：
10.1080/15287398709531058
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
M. Younes
中科院分区：
文献类型：
--
作者：
C. Siegers;M. Schenke;M. Younes
亚致死剂量的氯化镉(3 mg/kg静脉注射)、氯化汞(2 mg/kg静脉注射)或NaVO_3(6 mg/kg静脉注射)在24小时的观察期内不改变小鼠肝脏中还原型谷胱甘肽(GSH)的含量。在肾脏中，GSH含量有升高的趋势，尤其是在HgCl2处理后；在肺和脑中，GSH水平在所有三种金属处理后都显著降低。在所有组织中，当HgCl2大于NaVO_3大于Cd_2Cl2时，所有组织中GSH-S-芳基底物转移酶(CDNB；1-氯-2，4-二硝基苯)的活性都被增强。环氧底物[1，2-环氧基-3-(对-硝基苯氧基)丙烷]的谷胱甘肽S转移酶活性仅在肝脏中可测到，并在HgCl2和NaVO_3作用1和2 h后被抑制。结论：与体外实验结果相反，亚致死剂量的氯化镉、氯化汞或三氧化二钠对其毒性不同靶器官的GSH浓度和GSH结合酶活性没有影响。
Sublethal doses of CdCl2 (3 mg/kg iv), HgCl2 (2 mg/kg iv), or NaVO3 (6 mg/kg iv) did not alter the content of reduced glutathione (GSH) in the livers of mice during the 24-h observation period. In the kidneys, a tendency to increased GSH content was seen, especially after HgCl2 treatment; in lung and brain the GSH levels were significantly lowered upon the treatment with all three metals. The activities of GSH S-transferase toward an aryl substrate (CDNB; 1-chloro-2,4-dinitrobenzene) was enhanced in all tissues by the administration of HgCl2 greater than NaVO3 greater than CdCl2. The activity of GSH S-transferase toward an epoxide substrate [1,2-epoxy-3-(p-nitrophenoxy)propane was only measurable in the livers and was inhibited 1 and 2 h after the administration of HgCl2 and NaVO3. It is concluded that sublethal doses of CdCl2, HgCl2, or NaVO3 do not impair the GSH concentration and GSH-conjugating enzyme activities toward the aryl substrate in different target organs of their toxicity, which is in contrast to results obtained in vitro.
三甲基锡神经元毒性的发病机制。
DOI：
--
发表时间：
1981
期刊：
The American journal of pathology
影响因子：
--
作者：
Bouldin,TW;Goines,ND;Bagnell,RC;Krigman,MR
通讯作者：
Krigman,MR