The Neural Circuitry that Functions as a Switch for Courtship versus Aggression in Drosophila Males
The Neural Circuitry that Functions as a Switch for Courtship versus Aggression in Drosophila Males
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DOI：
10.1016/j.cub.2016.04.017
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发表时间：
2016-06-06
期刊：
影响因子：
9.2
通讯作者：
Yamamoto, Daisuke
中科院分区：
文献类型：
--
作者：
Koganezawa, Masayuki;Kimura, Ken-ichi;Yamamoto, Daisuke
在雄性黑腹果蝇中，求偶和攻击是以一种相互排斥的方式被诱导的，它会根据遇到的同种是雌性还是雄性而迅速选择这些行为剧目中的一个来运行，但这种决策背后的神经机制仍然不清楚。通过在脑神经元的一个子集中有针对性的兴奋和突触阻断，我们在这里证明，一个double-express阳性神经簇pC 1的细胞（类似于20个细胞）作为攻击触发中心，而fru阳性亚组分pC 1作为攻击触发中心。（类似于20个细胞）的pC 1作为求爱触发中心，并且这两个中心的互斥激活是通过由两个fru单阳性簇LC 1和mAL组成的双层抑制开关来实现的。据我们所知，这是第一份报告，以解开细胞身份的神经开关，管理的替代激活的侵略和求偶在动物王国。
Courtship and aggression are induced in a mutually exclusive manner in male Drosophila melanogaster, which quickly chooses one of these behavioral repertoires to run depending on whether the encountered conspecific is a female or male, yet the neural mechanism underlying this decision making remains obscure. By targeted excitation and synaptic blockage in a subset of brain neurons, we demonstrate here that the fruitless (fru)-negative subfraction (similar to 20 cells) of a doublesex-positive neural cluster, pC1, acts as the aggression-triggering center whereas the fru-positive subfraction (similar to 20 cells) of pC1 acts as the courtship-triggering center, and that the mutually exclusive activation of these two centers is attained by a double-layered inhibitory switch composed of two fru single-positive clusters, LC1 and mAL. To our knowledge, this is the first report to unravel the cellular identity of the neural switch that governs the alternative activation of aggression and courtship in the animal kingdom.