Selective suppression of excitatory synapses on GABAergic interneurons by norepinephrine in juvenile rat prefrontal cortical microcircuitry.
Selective suppression of excitatory synapses on GABAergic interneurons by norepinephrine in juvenile rat prefrontal cortical microcircuitry.
复制标题
去甲肾上腺素选择性抑制幼年大鼠前额皮质微电路中 GABA 能中间神经元的兴奋性突触。
DOI：
10.1016/j.neuroscience.2013.05.009
复制
发表时间：
2013
期刊：
影响因子：
3.3
通讯作者：
Gao,W-J
中科院分区：
文献类型：
--
作者：
Wang,H-X;Waterhouse,BD;Gao,W-J
大脑的去甲肾上腺素能系统被认为促进神经元过程，促进行为激活，警觉性和注意力。众所周知，在正常条件下，如唤醒和注意力，以及在施用精神兴奋剂和用于精神疾病的各种其他药物后，去甲肾上腺素（NE）可以在前额皮质中显著升高。然而，NE如何调节神经元活动和突触在当地的前额叶回路仍然是难以捉摸的。在这项研究中，我们表征了NE对幼年（出生后20-23天）大鼠前额局部回路中V层锥体神经元（P）和快速发放（FS）GABA能中间神经元之间的单个单突触连接的作用。NE选择性地抑制P-FS连接的兴奋性突触传递，但对P-P连接的兴奋性突触和FS-P连接的抑制性突触无明显影响。NE显然对以GABA能中间神经元为靶点的已识别突触发挥明显不同的调节作用，但对这一特定发育时期锥体神经元中的突触没有影响。这些结果表明，根据突触后靶点，NE在前额叶皮层的作用是突触特异性的，至少在幼年动物中是如此。
The noradrenergic system of the brain is thought to facilitate neuronal processes that promote behavioral activation, alertness, and attention. It is known that norepinephrine (NE) can be significantly elevated in the prefrontal cortex under normal conditions such as arousal and attention, and following the administration of psychostimulants and various other drugs prescribed for psychiatric disorders. However, how NE modulates neuronal activity and synapses in the local prefrontal circuitry remains elusive. In this study, we characterized the actions of NE on individual monosynaptic connections among layer V pyramidal neurons (P) and fast-spiking (FS) GABAergic interneurons in the juvenile (postnatal days 20–23) rat prefrontal local circuitry. We found that NE selectively depresses excitatory synaptic transmission in P–FS connections but has no detectable effect on the excitatory synapses in P–P connections and the inhibitory synapses in FS–P connections. NE apparently exerts distinctly different modulatory actions on identified synapses that target GABAergic interneurons but has no effect on those in the pyramidal neurons in this specific developmental period. These results indicate that, depending on the postsynaptic targets, the effects of NE in prefrontal cortex are synapse-specific, at least in the juvenile animals.