Differentiation of Pulpal Cells and Inductive Influences of Various Matrices with Reference to Pulpal Wound Healing
Differentiation of Pulpal Cells and Inductive Influences of Various Matrices with Reference to Pulpal Wound Healing
复制标题
DOI：
10.1177/002203458506400406
复制
发表时间：
1985-04
影响因子：
7.6
通讯作者：
T. Yamamura
中科院分区：
文献类型：
--
作者：
T. Yamamura
根据最近的文献，间充质细胞在各种组织和基质移植的动力学，以及参与牙本质桥形成的新的成牙本质细胞的起源进行了描述。进行了涉及牙髓、骨膜、软骨膜、处理过的牙本质和骨基质的植入的实验，以强调这些细胞产生硬组织的能力。通过光镜、电镜和放射自显影研究，阐明替代成牙本质细胞的来源。牙髓暴露后，牙髓细胞、内皮细胞和周细胞变成未分化的间充质细胞。这些间充质细胞分化为成牙本质细胞，随后产生牙本质基质。牙髓组织自体移植到非牙髓部位，精心制作骨（或骨牙本质）基质，但他们没有移植到管状牙本质。使用无菌大鼠进行的牙本质桥形成实验表明，牙髓组织具有内在的愈合潜力。因此，可以得出结论，牙髓组织的能力，阐述硬组织取决于它的环境。
Based on recent literature, the dynamics of mesenchymal cells in transplantation of various tissues and matrices, as well as the origin of new odontoblasts which participate in the formation of the dentin bridge, are described. Experiments involving implantation of pulp, periosteum, perichondrium, treated dentin, and bone matrices were performed to emphasize the capability of these cells to produce hard tissue. Light and electron microscopic and autoradiographic studies were carried out to clarify the origin of replacement odontoblasts. It appears that the pulp cells, endothelial cells, and pericytes become undifferentiated mesenchymal cells following pulp exposure. These mesenchymal cells differentiate into odontoblasts, which subsequently produce a dentin matrix. Pulp tissues auto-grafted to non-pulpal sites, elaborated bone (or osteodentin) matrix, but they did not graft to tubular dentin. An experiment on dentin bridge formation, using germ-free rats, demonstrated that the pulp tissue has intrinsic healing potential. Therefore, it was concluded that the ability of pulp tissue to elaborate hard tissues depends on its environment.