BIOCHEMICAL ASSESSMENT OF SEROTONERGIC AND CHOLINERGIC DYSFUNCTION AND CEREBRAL ATROPHY IN ALZHEIMERS-DISEASE
BIOCHEMICAL ASSESSMENT OF SEROTONERGIC AND CHOLINERGIC DYSFUNCTION AND CEREBRAL ATROPHY IN ALZHEIMERS-DISEASE
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DOI：
10.1111/j.1471-4159.1983.tb11838.x
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发表时间：
1983-01-01
影响因子：
4.7
通讯作者：
DAVISON, AN
中科院分区：
文献类型：
--
作者：
BOWEN, DM;ALLEN, SJ;DAVISON, AN
通过使用神经外科和尸检样本，检查整个颞叶以及额叶和颞叶新皮质中的血清素 [5-羟色胺，5-HT] 突触标记物是否存在阿尔茨海默病的变化。 [3H]丙咪嗪对[3H]5-HT结合的摄取和吲哚胺含量均显着减少，表明5-HT神经末梢受到影响。 [3H]5-HT 的结合也减少，而[3H]苯苯甲酸奎宁环酯、[3H]蝇蕈醇和[3H]二氢阿普洛尔的结合未改变。当阿尔茨海默病样本根据年龄进行细分时，[3H]5-HT 结合减少是年轻患者尸检样本的一个特征。所有阿尔茨海默病样本组（包括神经外科样本）的突触前胆碱能活性均降低。在整个颞叶中测量了五种被认为反映脑萎缩的标记物：细胞质、神经细胞膜和神经元周核。在阿尔茨海默氏病中，这种减少（平均 25%，范围 20-35%）被认为太大，而不仅仅是由于与基底前脑中假定的胆碱能核周和脑干中的单胺神经元相关的结构的损失。
Markers of serotonin [5-hydroxytryptamine, 5-HT] synapses in entire temporal lobe and frontal and temporal neocortex were examined for changes in Alzheimer''s disease by use of both neurosurgical and autopsy samples. Uptake of [3H]5-HT binding of [3H]imipramine, and content of indolamines were all significantly reduced, indicating that 5-HT nerve terminals are affected. Binding of [3H]5-HT was also reduced, whereas that of [3H]quinuclidinyl benzilate, [3H]muscimol and [3H]dihydroalprenolol were unaltered. When the Alzheimer''s samples were subdivided according to age, the reduction in [3H]5-HT binding was a feature of only autopsy samples from younger patients. Presynaptic cholinergic activity was reduced in all groups of Alzheimer''s samples, including neurosurgical specimens. Five markers, thought to reflect cerebral atrophy, cytoplasm, nerve cell membrane and neuronal perikarya were measured in the entire temporal lobe. In Alzheimer''s disease the reductions (mean 25%, range 20-35%) were thought to be too large to be due only to loss of structures associated with the presumed cholinergic perikarya in the basal forebrain and monoamine neurons in the brain stem.