The remaining unknowns: a mixed methods study of the current and global health research priorities for COVID-19.
The remaining unknowns: a mixed methods study of the current and global health research priorities for COVID-19.
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DOI：
10.1136/bmjgh-2020-003306
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发表时间：
2020-07-01
影响因子：
8.1
通讯作者：
Lang, Trudie
中科院分区：
文献类型：
--
作者：
Norton, Alice;De La Horra Gozalo, Arancha;Lang, Trudie
简介：2020 年 3 月，世界卫生组织在全球 400 名专家的审议基础上发布了全球研究路线图，旨在协调和加速全球抗击 COVID-19 的研究响应。三个月过去了，这种疾病和我们的理解都发生了显着的变化。随着我们现在在非常不同的背景下应对大流行，随着知识的增加，我们寻求以世界卫生组织的工作为基础，以获得对这些初步优先事项的更当前和全球的视角。方法：我们进行了一项混合方法研究，征求全球研究界的意见，以（1）评估世界卫生组织早期路线图优先事项中的哪些仍然是最紧迫的； (2) 了解它们在不同环境、地区或国家是否仍然有效； (3) 确定任何新出现的优先事项。 结果：对大量综合数据的专题分析表明，世卫组织路线图具有全球相关性；然而，新的重要优先事项已经出现，特别是与低收入和中低收入国家（资源较少的国家）相关的优先事项，这些国家的卫生系统面临着巨大的竞争压力。我们还发现，从优先考虑疫苗和治疗方法的开发，转向注重评估各种公共卫生干预措施和措施的有效性、风险、益处和信任。我们的研究结果还深入了解了这些研究重点的时间性质，强调了只能在病毒传播期内进行的研究的紧迫性，以及其他重要的研究问题，但可以在传播期之外得到解答。这两类研究都是帮助抗击这一流行病的关键，但对于确保我们为未来做好更好的准备也很重要。结论：我们希望这些发现将有助于指导包括多边合作伙伴、研究资助者、公共卫生从业者、临床医生和民间社会在内的广泛研究系统的决策。
INTRODUCTION: In March 2020, the WHO released a Global Research Roadmap in an effort to coordinate and accelerate the global research response to combat COVID-19 based on deliberations of 400 experts across the world. Three months on, the disease and our understanding have both evolved significantly. As we now tackle a pandemic in very different contexts and with increased knowledge, we sought to build on the work of the WHO to gain a more current and global perspective on these initial priorities.METHODS: We undertook a mixed methods study seeking the views of the global research community to (1) assess which of the early WHO roadmap priorities are still most pressing; (2) understand whether they are still valid in different settings, regions or countries; and (3) identify any new emerging priorities.RESULTS: Thematic analysis of the significant body of combined data shows the WHO roadmap is globally relevant; however, new important priorities have emerged, in particular, pertinent to low and lower middle-income countries (less resourced countries), where health systems are under significant competing pressures. We also found a shift from prioritising vaccine and therapeutic development towards a focus on assessing the effectiveness, risks, benefits and trust in the variety of public health interventions and measures. Our findings also provide insight into temporal nature of these research priorities, highlighting the urgency of research that can only be undertaken within the period of virus transmission, as well as other important research questions but which can be answered outside the transmission period. Both types of studies are key to help combat this pandemic but also importantly to ensure we are better prepared for the future.CONCLUSION: We hope these findings will help guide decision-making across the broad research system including the multilateral partners, research funders, public health practitioners, clinicians and civil society.